IndraLab

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"N-acetylcysteine can also downregulate NFkB, with resultant reduction in neutrophil chemoattractant messenger RNA (mRNA) and alveolitis in a rat model of lung injury."
| PMC

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"N-acetylcysteine can also downregulate NFkB, with resultant reduction in neutrophil chemoattractant messenger RNA (mRNA) and alveolitis in a rat model of lung injury.Vitamin C and E administration in the critically ill reduced duration of mechanical ventilation and ICU stay without decreasing the incidence of ARDS.101Statins were introduced into clinical practice as cholesterol-lowering agents through inhibition of HMG-CoA reductase and have since been shown to possess pleiotropic actions both dependent and independent of HMG-CoA reductase inhibition."
| PMC

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"N-Acetylcysteine also has been shown to inhibit NFKB activation by several stimuli including ILl, phorbol myristate acetate, TNF and lipopolysaccaride [16,15]."