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USP12 inhibits PHLPP1. 3 / 3
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"Contrarily, a different study shows USP12 suppresses Akt-dependent cell growth of tumor cells by stabilizing tumor suppressor PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) [ 13 ]."
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"However, USP12 has also been shown to inhibit AKT-dependent cell survival by stabilizing the pro-apoptotic phosphatases PHLPP1 and/or PHLPPL ."
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"Because PHLPP1 is a potent negative regulator of the PI3-kinase and Akt pathway, we hypothesized that WDR48 and USP12 might suppress Akt signaling by stabilizing PHLPP1."
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