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USP19 increases the amount of MGMT. 2 / 2

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"We found that knockdown of USP19 dramatically decreased MGMT protein level, which can be rescued by proteasome inhibitor MG132 (Figure 1B)."

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"As shown in Figure 1C,D, depletion of endogenous USP19 by two USP19‐specific shRNAs markedly decreased protein level, but not the MGMT mRNA level, suggesting that USP19 regulates MGMT through post‐translational modification."

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IndraLab

Statements

USP19 increases the amount of MGMT. 2 / 2

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