IndraLab

Statements

IL6ST binds ADAM17. 8 / 8
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"To reveal the mechanism of sIL-6R production, we investigated the expression of ADAM17, an important mediator of membrane bound IL-6R shedding."
27863335
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"Expanding the therapeutic armamentarium of systemic immunosuppressive agents to treat the more aggressive and recalcitrant cases is of paramount importance in the management of JIA-U, one of the most challenging types of uveitis.IL-6 binds to a membrane-bound IL-6 receptor (IL-6R) or a soluble receptor (sIL-6R) generated by the cleavage of IL-6R by a membrane-bound metalloprotease (ADAM 17)."
36979992
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"This may decrease affinity between IL6R and ADAM17, potentially allowing for faster release upon cleavage and higher turnover rate."
39417133
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"It was unclear, however, whether proteolysis in patients treated with anti-IL-6R therapeutics would still function or whether the therapeutics would somehow interfere with the interaction of ADAM17 an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30557809
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"As shown in XREF_FIG, both IL-6R and IL-6R-5N could be efficiently coimmunoprecipitated with MPD17-CANDIS, indicating that the glycans are not mandatory for the IL-6R and ADAM17 interaction."
28060820
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"The main mode of production of sIL-6Rα is selective splicing of precursor mRNA or cleavage of membrane bound IL-6R by a disintegrin and metalloprotease 10 (ADAM10) and ADAM17 [29]."
36291659
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"In disease conditions, Adam 17 cleaved soluble form of IL-6R (sIL-6R) binds to IL-6 and activate gp130, it mediates trans -signaling in IL-6R deficient cells leading to inflammation through NF-κB acti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36084909
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"One example of such regulation by nonsynonymous variants is IL6R, which had a strong cis-pQTL that was primarily associated with the coding-variant rs2228145 p.D358A (and rs12730935 which was in perfect linkage disequilibrium; plasma=1.6×10 CSF= 1.3×10 ), as this variant leads to increased cleavage by ADAM10 and ADAM17 of membrane bound IL6R ."
34239129