IndraLab

Statements

ADAM17 binds IL6ST. 3 / 3
| 3
reach
"As shown in XREF_FIG, both IL-6R and IL-6R-5N could be efficiently coimmunoprecipitated with MPD17-CANDIS, indicating that the glycans are not mandatory for the IL-6R and ADAM17 interaction."
28060820
reach
"One example of such regulation by nonsynonymous variants is IL6R, which had a strong cis-pQTL that was primarily associated with the coding-variant rs2228145 p.D358A (and rs12730935 which was in perfect linkage disequilibrium; plasma=1.6×10 CSF= 1.3×10 ), as this variant leads to increased cleavage by ADAM10 and ADAM17 of membrane bound IL6R ."
34239129
reach
"To reveal the mechanism of sIL-6R production, we investigated the expression of ADAM17, an important mediator of membrane bound IL-6R shedding."
27863335