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USP21 deubiquitinates PPP3. 3 / 3
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"USP16 not only deubiquitinates calcineurin A to facilitate its interaction of NFAT and activation of inflammation genes but also deubiquitinates IKKβ, a key kinase involved in p105 phosphorylation and activation [36,47]."
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"For example, during cell immune response, cytoplasmic USP16 deubiquitinates calcineurin A, allowing it to dephosphorylate and activate NFAT (Figure 4G)."
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"In peripheral T cells, USP16 is instrumental for cell maintenance and proliferation by deubiquitinating calcineurin A (22)."
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