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USP22 increases the amount of extracellular matrix. 3 / 3
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"In addition to promoting EMT, USP22 overexpression upregulated the expression of TGF-β1 and ECM components including FN, Collagen I, and Collagen Ⅳ under HG conditions ( Fig. 3 F)."

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"Under NG conditions, the half-life of Snail1 was about 0.8 h, whereas HG stimulation significantly increased the of Snail1 level and extended its half-life to 1.4 h ( Fig. 7 A), indicating that HG inc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"In vitro experiments confirmed that USP22 promoted the EMT process to increase the expression of ECM components."