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USP5 inhibits USP5. 3 / 3
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"Mebendazole synergizes with WP1130, an inhibitor of USP5, because mebendazole downregulates USP5 expression and WP1130 inhibits USP5 deubiquitinase activity."

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"Regarding the proliferative capacity of the cells, the CCK-8 experiments demonstrated that USP5 overexpressing T24 cells had significantly increased proliferation and USP5 knockdown T24 cells had significantly decreased proliferation compared with the control group (P<0.05; Fig. 2D)."

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"These results indicate that over-expression of USP5 could inhibit SVCV replication.To further verify the antiviral effect of USP5, three pairs of interfering RNAs were designed and the siRNA with the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"