IndraLab

Statements

OTULIN activates GZMM. 3 / 3
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"Nonetheless, OTULIN overexpression strongly impairs coprecipitation of ubiquitinated RIPK1 with NEMO in TNF treated cells, whereas small interfering RNA mediated depletion of OTULIN increases the early accumulation of Met1-Ub on RIPK1 XREF_BIBR."
25060092
reach
"These results indicate that OTULIN regulates cell death in a DUB-dependent manner.The increased Met1-Ub observed in cells lacking OTULIN implicated enhanced LUBAC function in cell death susceptibility[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31825842
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"Activation of the MAP kinases p38 and JNK1/2 was only slightly increased by OTULIN depletion, consistent with the notion that OTULIN disassembles Met1-Ub primarily involved in IKK activation."
23806334