IndraLab

Statements

OTUB1 inhibits DNA damage response, detection of DNA damage. 3 / 3
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"It was reported that Otub1, a deubiquitinase, also negatively regulates the DDR in a catalytically independent manner by regulating the activity of UBC13, an E2 ubiquitin conjugating enzyme for RNF8."
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"How does OTUB1 inhibit ubiquitination-dependent DDR?"
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"revealed that OTUB1 negatively regulates the DDR by inhibiting the RNF168 pathway and showed that depletion of the negative DDR regulator is able to partially rescue the suppressed IR induced 53BP1 focus formation caused by ATM inhibitor."
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