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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OTUB1 inhibits DNA damage response, detection of DNA damage. 3 / 3

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"It was reported that Otub1, a deubiquitinase, also negatively regulates the DDR in a catalytically independent manner by regulating the activity of UBC13, an E2 ubiquitin conjugating enzyme for RNF8."

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"How does OTUB1 inhibit ubiquitination-dependent DDR?"

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"revealed that OTUB1 negatively regulates the DDR by inhibiting the RNF168 pathway and showed that depletion of the negative DDR regulator is able to partially rescue the suppressed IR induced 53BP1 focus formation caused by ATM inhibitor."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...