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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP1 inhibits cell growth. 3 / 3

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"Knockdown of USP1 by siRNA decreased B-ALL cell growth and induced apoptosis."

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"Pimozide is a USP1 inhibitor that inhibits leukemic cell growth through degradation of ID1 proteins [ xref ]."

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"Interestingly, Pimozide promoted ID1 degradation, decreased USP1 levels, and caused a dose dependent inhibition of K562 cell growth in vitro with induction of apoptosis (XREF_FIG), though at a higher drug concentrations as compared to SJB2-043."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...