IndraLab

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USP17L2 activates epithelial to mesenchymal transition. 11 / 11
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"The authors correlated the stunting of tumor growth with the antagonizing role of palbociclib in DUB3-driven CDK4/6 activation, consequently preventing EMT and metastases [161]."
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"By contrast, ectopic expression of Dub3 induces EMT through an upregulation of Snail."
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"Dub3 is overexpressed in breast cancer; knockdown of Dub3 resulted in Snail1 destabilization, suppressed EMT and decreased tumour cell migration, invasion, and metastasis."
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"Dub3 expression induces EMT."
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"Here our studies indicate that DUB3 is crucial to induce EMT through the stabilization of SNAIL1 protein in breast cancer."
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"Together, these data indicate that Dub3 can induce EMT (luminal to basal like phenotype conversion) by stabilizing Snail1 in breast cancer cells."
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"DUB3 binds, deubiquitylates and increases cellular levels of the EMT transcription factor SNAIL1 (REF."
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"Additionally, overexpression of DUB3 induced E-cadherin gene repression and EMT [ 70 ]."
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"Consistently, Dub3 expression induced a morphologic change indicative of EMT (XREF_FIG), including downregulation of epithelial markers (E-cadherin, Claudin-7 and Occludin) and the upregulation of mesenchymal molecules (N-cadherin and Vimentin) (XREF_FIG, XREF_SUPPLEMENTARY)."
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"14 We previously demonstrated that CDK4/6 binds and phosphorylates DUB3 at Ser41, which is essential for the activation of DUB3 and stabilization of Snail1, thereby promoting EMT and metastasis in breast cancer."
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"In fact, DUBs involved in Snail regulation so far are shown to be induced differently, while USP27x is induced by TGF-β; DUB3/USP17L2 seems to play a role in CDK4/6-mediated activation of EMT, whereas OTUB1 is under the transcriptional regulation of oestrogen-related receptor alpha, and USP37 regulation is induced during EMT via the stimulation of the hedgehog signalling pathway."
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