IndraLab

Statements

Fentanyl inhibits KCNH2. 8 / 8
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"35 Oxycodone and fentanyl reduce HERG current in vitro, XREF_BIBR, XREF_BIBR and as do cocaine and cocaine metabolites, XREF_BIBR, XREF_BIBR but none of these drugs affect the I Ks current."
21895724
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"Based on the current literature, methadone, oliceridine, l-α-acetylmethadol (LAAM), and fentanyl were found to inhibit the HERG channel function and were associated with QTc prolongation."
37015297
ctd
No evidence text available
28551711
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"As well, high pH potentiated the fentanyl mediated block of hERG channels, with an IC 50 at pH 8.4 being 7-fold lower than that at pH 7.4."
32321735
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"When a voltage protocol that mimics a human ventricular action potential (AP) was used, fentanyl blocked I hERG with an IC 50 of 0.3 muM."
30665971
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"When hERG tail currents upon -50 mV repolarization following a 50 mV depolarization were analyzed, fentanyl and naloxone blocked hERG current (I hERG) with an IC 50 of 0.9 muM and 74.3 muM, respectively, while norfentanyl did not block."
30665971
reach
"Thus, in addition to a greater susceptibility due to the presence of hERG1b in the human heart, hERG channel block by fentanyl can be exacerbated by certain conditions such as hypoxia, hypokalemia, or alkalosis, which may increase the risk of fentanyl induced ventricular arrhythmias and sudden death."
32321735
reach
"We have demonstrated that fentanyl blocks hERG current (I hERG) at concentrations that overlap with the upper range of postmortem blood concentrations in fentanyl related deaths."
32321735