IndraLab

Statements


SCN8A decreases the amount of IL1B. 4 / 4
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"Herein, we have shown that MED can significantly inhibit the ox-LDL-induced expression of TNF-alpha, IL-6, and IL-1beta both in RAW264.7 cells and in plaque lesion areas, which suggests that MED can suppress inflammatory responses in atherosclerosis."

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"Consistently, MED significantly suppressed the levels of serum IL-1beta and IL-6 (XREF_FIG)."

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"XREF_FIG, MED suppressed the protein levels of TNF-alpha, IL-6, and IL-1beta in plasma and the mRNA levels of TNF-alpha, IL-6, and IL-1beta in the aortic arch."

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"Furthermore, MED could significantly suppress the mRNA levels of TNF-alpha, IL-1beta and IL-6 induced by LPS (XREF_FIG), indicating that MED inhibits LPS induced cytokine expression at the transcriptional level."