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USP15 deubiquitinates E3_Ub_ligase. 2 / 2
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"Additionally, USP15 can deubiquitinate the E3 ligase SMURF2."

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"USP15 deficiency enhances NFATc2 activation in naive CD4 T cells, because USP15 deubiquitinates and stabilizes the E3 ubiquitin ligase MDM2, which negatively regulates NFATc2 activation and cytokine i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"