IndraLab

Statements

Calcium(2+) activates KCNMA1. 209 / 229
1 2 | 3 206
reach
"Therefore, activation of the BK channel could offset vasoconstriction and prevents vasospasm of uterine arteries, which probably contributes to the refractoriness of uterine arteries to vasoconstrictors during normal pregnancy.In VSMCs, the BK channel is primarily activated by Ca sparks mediated by RyRs [270]."
36674858
reach
"Potential molecular targets include the K ATP channel ( Lu et al., 2002 ) and the calcium-activated BK channel (BK Ca ) ( Campbell et al., 1996; Li and Campbell, 1997 )."
28526610
reach
"The identity of the specific potassium channels involved seems to be very cell type specific and indeed both Ca activated K channels (KCNMA) (Garcia et al., 1991) and KV1.3 (KCNA3) channels (Garcia-Calvo et al., 1993) have been separately identified on the basis of toxin inhibition (charybdotoxin and margatoxin, respectively)."
30519193
reach
"The store BK channel is activated by positive shifts in the luminal potential and luminal Ca 2+ increases [32,33] ."
16938295
reach
"BK channel is activated by increased Ca 2+ spike released by ryanodine receptors, presents on smooth endoplasmic reticulum in SMC."
26424038
reach
"Therefore, it seems that mechanisms that prevents Ca influx and/or decrease Ca level despite high cGMP level exist in AFD, which is consistent with our previous finding that SLO K channels contribute to decrement of Ca level in AFD after its increment by warming [40]; both SLO-1 and SLO-2 channels are activated by Ca , and the resulting K+ efflux may prevent Ca influx possibly by inactivating voltage-dependent Ca channels."
36472979
reach
"Although both channels are primarily defined as voltage gated, SLO1 is also activated by Ca [92], while SLO3 is triggered by intracellular alkalinization [86,93]."
37760960
reach
"The alpha subunit is encoded by the calcium activated potassium channel subunit alpha a-1 (Kcnma1) gene in humans and mice, and is expressed in a wide range of tissues."
28316260
reach
"The effects of BK channel blockers are more prominent during repetitive stimulation, in which BK channel activity is promoted by a transient calcium buildup."
18547679
reach
"Large conductance BK-type K channels (Slo1) are activated by voltage and intracellular Ca 2+, play an important role in synaptic physiology, and are present in parts of the brain that contain synaptic Cu 2+ and Zn 2+."
18443360
reach
"We identified three upregulated calcium-activated potassium channel genes (BK channel), two in Adina and one Zhaodong."
36570949
reach
"Calcium-activated potassium channels are divided into large conductance calcium-activated potassium channels(KCa1.1), medium conductance calcium-activated potassium channels(KCa3.1), and small conductance calcium-activated potassium channels(KCa2.1-2.3)."
36703789
reach
"Maxi-K, which has a large conductance, has a low open probability at baseline, but can be activated by increases in intracellular Ca 2+ and membrane depolarization [XREF_BIBR]."
19448535
reach
"Many epithelia express cAMP and/or Ca -stimulated K channels, e.g., cAMP-activated Kv7.1 (coded by KCNQ1) and calcium-activated KCa3.1 or KCa1.1 channels (coded by KCNN4 and KCNMA1, respectively), in addition to luminal anion channels, including CFTR and/or calcium-activated Cl channels (CaCC) (e.g., TMEM16/ANO1) (reviewed in [46])."
36534232
reach
"Voltage- and calcium activated SLO-1 and SLO-2 BK potassium channels act redundantly downstream of NSY-5 to antagonize calcium channel mediated signaling in promoting the AWC ON subtype [XREF_BIBR]."
28357469
reach
"FMRP was also shown to interact with the auxiliary beta4 subunit of the calcium activated potassium (BK) channel; this interaction increases calcium dependent activation of the BK channel."
26864773
reach
"BK channel modulation by positively charged peptides and auxiliary gamma subunits mediated by the Ca 2+ -bowl site."
37130264
reach
"The galanin-induced increase of BK current was not affected ( Fig. 3 C), excluding that influx of extracellular Ca 2+ underlies the BK channel activation."
24602615
eidos
"BK channel activation by Ca 2 + sparks was recorded using perforated patch electrophysiology to record spontaneous transient outward currents ( STOCs ) ."
35557207
reach
"Calcium sparks, a highly localized calcium transients originating at the triad, are mediated by ryanodine receptors and L-type Ca 2+ channels and cause BK channel activation, which is responsible for muscle inactivation."
20019812
reach
"Although both of them are voltage gated, SLO1 is additionally activated by Ca 2+ [XREF_BIBR], whereas SLO3 is activated by an alkaline pH i [XREF_BIBR, XREF_BIBR]."
| PMC
reach
"In addition to Cys911, modification of Cys430 in the cytoplasmic regulator of potassium conductance domain alters the Ca -dependent activation of Slo1 (Zhang and Horrigan, 2005; Zhang et al., 2006)."
39099341
reach
"This suggests that the GOF BK channel is also activated by nicotine-induced Ca entry and membrane depolarization, and its large K conductance overrides CaCC-mediated depolarization and prevents the formation of the CaCC-VGCC positive feedback."
40106550
reach
"LRRC26 knockdown did not alter Ca 2+ sparks, but reduced BK channel voltage-sensitivity, which reduced channel apparent Ca 2+ -sensitivity and transient BK current frequency and amplitude in myocytes."
24906643
reach
"Elevated intracellular Ca concentration is known to increase BK channel conductance [62]."
39397241
reach
"Cell membrane voltage and intracellular Ca 2+ activate Slo1 synergistically, making it a central regulator of various physiological processes that couple electrical signaling to Ca 2+ -mediated events such as muscle contraction, hormone secretion, and neuronal excitability XREF_BIBR, XREF_BIBR."
27974795
reach
"We further show that flow stimulated Ca 2+ influx through TRPV5 and TRPV6 is sufficient to activate Slo1 encoded Ca 2+ -activated maxi-K, which are present in DCT2 and CNT where flow stimulated K + secretion is known to take place [XREF_BIBR]."
24001793
reach
"The gene that was up-regulated, Kcnmb1 (Calcium activated potassium channel subunit beta-1), is a regulatory subunit of the calcium activated potassium KCNMA1 channel, controlling both the sensitivity and gating kinetics of this channel."
24055786
reach
"Electroreception through ampullae of Lorenzini in the little skate, Leucoraja erinacea, involves functional coupling between voltage-activated calcium channels (CaV1.3, cacna1d) and calcium-activated big-conductance potassium (BK) channels (BK, kcnma1)."
37681857
reach
"It was observed that: (1) single BK channels have similar current-voltage relationships, voltage-dependence and calcium sensitivity; (2) BK currents in cells with a strong buffering of the BK channel activator calcium have similar current-voltage relationships; (3) the iloprost-induced concentration-dependent increase of the BK current is larger in WKY compared to SHR; (4) the effects of activators of the PKA pathway, the catalytic subunit of PKA and the potent and selective cAMP-analogue Sp-5,6-DCl-cBIMPS on BK currents are similar."
39000253
reach
"Finally, it should be noted that the impairment of cognitive function by THD (administered 3 ​h before testing) involves a cereblon mediated modulation of the large-conductance calcium-activated potassium channel (BK channel, K 1.1) in the hippocampus (Choi et al., 2018a, Choi et al., 2018b)."
36568268
reach
"For example, Slo1 BK channels are allosterically activated by both intracellular Ca 2+ and membrane depolarization."
25825171
reach
"The up-regulation of the calcium-activated potassium channel, subfamily M, and alpha member 1 (KCNMA1 or KCa1.1) in combination with verapamil (a drug used in the treatment of cardiac arrhythmias and the inhibition of transmembrane Ca flux) [180] potentiates the cytotoxic effect of cisplatin against ESCC (Table 2) [130]."
37408210
reach
"18,19 Maxi-K channel opening stimulated by Ca 2+ in the presence of a pharmacological opener would act to limit further Ca 2+ entry, thus interrupting the potentially fatal neurotoxic cascade initiate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12067560
reach
"Maxi-K channel opening stimulated by Ca 2+ and the pharmacological opener would function to limit further Ca 2+ entry by hyperpolarizing neurons, thereby reducing voltage dependent calcium entry point[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11909708
reach
"Having determined that ChTX diminishes ischemia induced depression of fEPSPs, we asked if BK channel activation is caused by the increased [Ca 2+] i that occurs during OGD."
26934214
reach
"Second, SLO1 has several Ca binding sites and is activated by a broad range of Ca concentrations [58,61,66]."
37446382
reach
"XREF_BIBR, XREF_BIBR We also compare Slo3 pharmacological sensitivity to that of its closely related homologue, the Ca 2+ - and voltage activated Slo1 (or BK-type) K + channel."
19934650
reach
"Second, BK channel was activated by Ca influx increase induced by H S. Naik et al. (2016) reported Na S increased sulfhydration of transient receptor potential vanilloid type 4 channels in aortic endothelium cells."
35721210
reach
"Based on their electrophysiological properties, KCa can be generally divided into three subfamilies: large conductance calcium-activated potassium channels (BK or maxi-K) with single-channel conductan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19481607
reach
"Since the Ca 2+ or voltage sensor for BK channel activation can act relatively independently to each other XREF_BIBR, XREF_BIBR, it is thus implied that the activation conformation of BK channel induced by variant cytoplasmic Ca 2+ concentrations may be different."
21445248
reach
"However, specific knockdown of the Ca²⁺-activated potassium channel β3 auxiliary subunit (KCNMB3) suppresses BK channel activation in microglia, attenuating microglial activation and pain-related molecule release, ultimately alleviating hyperalgesia (152)."
40264787
reach
"We hypothesized that in M4, Ca 2+ that enters through UNC-2 and UNC-36 activates SLO-1, thereby truncating neuronal depolarization and inhibiting vesicle fusion."
25378475
reach
"For both inside-out and outside-out configurations, Slo1 channels were activated by 300 muM cytosolic Ca 2+ at pH 8.5, while MC13 channels were activated with pH 8.5 with no Ca 2+."
19934650
reach
"However, whether GMQ or other structurally similar compounds have any perturbations on different types of ion channels in endocrine or neuroendocrine cells remains largely unknown.The large-conductanc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29477572
reach
"However, the beta2ND subunit has different effects on the Ca 2+ dependent activation of the two Slo1 orthologs."
21123563
reach
"Mutations in the genes encoding the large-conductance calcium-activated potassium channel, especially KCNMA1 encoding its alpha-subunit, have been linked to several neurological features, including intellectual disability or autism."
35509069
reach
"Apical Kcnma1 is activated by Ca 2+ XREF_BIBR."
26346926
reach
"Third, the BK channel can be independently activated by Ca 2+ or voltage, and it can open in the absence of Ca 2+."
25346693
eidos
"While it is known that BK channels are activated by voltage and Ca 2 + , and that voltage and Ca 2 + activations interact , less is known about the mechanisms involved ."
32513714
reach
"Notably, inositol 1,4,5-trisphosphate (IP ) receptors were identified as a cholesterol-sensitive source of BK channel-activating Ca in glioma cells [64]."
36988883
reach
"These genes encode a BK calcium activated potassium channel SLO-1 and an NPQR-type voltage gated calcium channel UNC-2 and UNC-36."
25378475
reach
"Using a ramp command over a -100 to -30 mV range with paxilline or mibefradil treatment further revealed LVA outward current that activated just subsequent to LVA inward calcium current, indicating that Cav3 calcium influx can activate KCa1.1 above ~-70mV."
24413887
reach
"Removal of extracellular Ca 2+, the influx of which is required to activate Slo, resulted in a similar reduction (36%; 55.8 +/- 3.2 pA/pF), consistent with ChTX blocking only the Slo mediated component of I Kfast (data not shown)."
17147779
eidos
"Literature reports that BK channels are activated in Vero cells during hypotonic stress , where cells are submitted to a 45 % less NaCl environment , in which BK channels were activated by Ca 2 + released by intracellular stores 38 ."
| DOI
reach
"Ca 2+ activates the BK channel SLO-1, which truncates the rise in membrane potential, preventing activation of the L-type voltage gated calcium channel EGL-19."
25378475
reach
"Therefore, calcium entry through a single Cav3 calcium channel is insufficient to activate KCa1.1 even though the two proteins are in close proximity."
24413887
reach
"In addition, an SNP in potassium calcium-activated channel subfamily M alfa-1 (KCNMA1) gene was associated with disability score with genome-wide significance (re1516512, P=2.33×10 ) and ATM (OR=1.77, P=0.011)."
37091460
reach
"It has been suggested that, particularly at lower levels of vessel contractility, NO-induced PKG-mediated activation of the BK channel is weaker than NO-induced [Ca ] decrease–mediated deactivation of the BK channel and that the overall decrease in BK channel activity determines the role of BK channels as limiters of the effect of NO."
40213146
reach
"It was suggested that at higher levels of vessel contractility, NO-induced PKG-mediated activation of the BK channel is stronger than NO-induced [Ca ] decrease–mediated deactivation of the BK channel and that the overall increase in BK channel activity determines the role of BK channels as facilitators of the effect of NO."
40213146
reach
"The large-conductance voltage- and calcium activated human Slo1 BK Ca channel is a critical member of the high-conductance Slo family of K + channel XREF_BIBR - XREF_BIBR."
28474046
reach
"XREF_BIBR A syndrome of generalised epilepsy with paroxysmal movement disorders has been shown to be caused in one kindred by a dominant missense mutation in the calcium activated potassium channel gene KCNMA1."
26558925
reach
"This Ca -independent activation of the BK channel is reinforced by the fact that the time constant of current stimulation was three orders of magnitude faster than the averaged diffusion-limited time it would take Ca to bind the channel during depolarization (Cui et al., 1997)."
34744788
reach
"However, there have been few studies on the mechanism underlying the TRPC6 promotion of glioma progression.Large-conductance calcium-activated potassium channels, also known as K Ca 1.1/BK Ca /MaxiK/S[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35489424
reach
"Other ion transporters genes enriched in ionocytes include subunits of the epithelial sodium channel (ENaC) beta subunit, ClC chloride channel subunit barttin (BSND), sodium/potassium/chloride cotransporter type 1 (NKCC1, SLC12A2), subunits of the vacuolar proton pump (V-ATPase), the calcium-activated potassium channel (KCNMA1) and the Slc9 family member of Na /H exchangers (NHE7) (Plasschaert et al., 2018)."
38505263
reach
"KCNMA-1, a gene that encodes the α-subunit of the large conductance calcium-activated potassium channel (BK channel), has been associated with ARHL80–82."
39992186
reach
"In this study, we hypothesized that PKG may be acting on calcium activated large-conductance Slo Kth channels, or BK channels."
30484391
reach
"However, Ca ++ increase in the context of strong depolarization triggered by ATP may activate KCa1.1."
28507328
reach
"The Slo1 alpha channel activation by Ca 2+ becomes observable at> = ~ 100 nM Ca 2+ (Cui et al., 1997; Jan and Jan, 1997)."
12719228
reach
"The opposite segmental functionality of the proximal and distal colon with regard to potassium ion movement can potentially be explained by the increased expression of the potassium–calcium-activated channel subfamily M alpha 1 (KCNMA1 or BK channels) in the proximal colon (Figure 2)."
35626748
reach
"Similarly, intracellular zinc activates the large-conductance Ca activated Slo1 potassium channel (BK) via a histidine residue on a cytoplasmic domain of the protein."
33460731
reach
"Slo1 channels are activated by increases in Ca 2+ nearby Ca 2+ -recognition sites in the slo1 cytosolic tail: one high-affinity and one low-affinity sites locate to the Regulator of Conductance for K + (RCK) 1 domain, while another high-affinity site locates within the RCK2 domain."
34969832
reach
"One group includes the BK channel that has large single-channel conductance ranging from 100 to 300 pS [23,24] and is activated by micromolar [Ca ] and membrane depolarization [23,25]."
36674858
reach
"However, with respect to [34] we also include the fast potassium current SHL1 and calcium-activated potassium current SLO1."
38551921
reach
"Considering that BK channel activation induced by IP3-induced Ca release provides an important negative feedback mechanism to protect against overresponse to vasoactive agonists [22,23], loss of coupling between IP3R-BK would induce BK dysfunction, thereby increasing the sensitivity of the blood vessels to agonist stimuli and leading to vascular hypertrophy and hyperplasia."
37446080
reach
"Given the double sensitivity to both Ca and voltage, the BK channel is activated cooperatively by a cytoplasmic Ca increase and membrane depolarization [73,74,75,76]."
38136613
reach
"The properties of the large-conductance K channel are consistent with its identification as a calcium activated maxi K channel described in a variety of tissues."
2782434
reach
"Similarly, a D434G mutation that produces an increase in Ca sensitivity that potentiates BK channel activity [231] was described in individuals affected by epileptic seizures and/or PNKD [232]."
36834817
reach
"Specifically, we targeted BK channels, or calcium activated large-conductance Slo Kth channels, which have been shown to have a ten-fold increase in Kth conductance compared to classic voltage gated Kth channels (Pallotta, Magleby, & Barrett, CONTACT K. Dawson-Scully ken.dawson-scully@fau.edu beta 2018 Informa UK Limited, trading as Taylor & Francis GroupDepartment of Biological Sciences, Florida Atlantic University, Boca Raton, FL, USA JOURNAL OF NEUROGENETICS2471981; Stefani et al., 1997)."
30484391
reach
"Therefore, we have quantified the mRNA expression of the large-conductance calcium activated potassium channel gene MaxiK XREF_BIBR."
26980664
reach
"The latter response denotes that basal Ca 2+ concentrations promote BK channel potentiation, whereas high concentrations (> 10 muM) induce inhibition."
25346693
reach
"The large-conductance calcium-activated potassium channel, or BK channel, is located throughout the peripheral and central auditory system."
34861480
reach
"In the case of the calcium-activated potassium channel Slo and its modulator Slob, analyses of mutant phenotypes more directly implicate these factors in the circadian control of locomotor activity."
18241855
reach
"The BK channel in VSMCs of uterine arteries is activated by an increase in [Ca ] , and has unitary conductance of 100–200 pS [21,236]."
36674858
reach
"Resin acids, which are primarily found in pine resin, and their chemical derivatives promote the opening of several voltage gated potassium (K V) channels and the voltage gated and calcium activated BK channel."
33683319
reach
"Slack channels are insensitive to the large conductance calcium-activated K + (BK Ca or maxi-K) channel blocking agent iberiotoxin and the BK Ca channel opener NS-1619, but are inhibited by millimolar[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16876206
reach
"Kcnma1, also known as the BK Ca channel, is activated by both elevated [Ca 2+] i and membrane depolarization."
24736375
reach
"We speculate that activation of the maxi K +-channels caused by an increased intracellular Ca t +-concentration during the process of bone resorption, may inactivate resorption activity."
8318532
reach
"The well-studied large-conductance Ca 2+ - and voltage-activated K + Slo1 (BK, Maxi-K, or KCa1.1) channels are dually activated by membrane depolarization and intracellular Ca 2 + ( 2 )."
38637987
reach
"Thus, at positive membrane potential, the activation of the BK channel caused by ATP was sufficient to counterbalance the inhibition of the BK channel caused by the chelation of free calcium by ATP; at negative membrane potential, however, the effect of ATP on P open was more inhibitory than would be expected, even bearing in mind the chelation of free calcium by ATP."
23284908
reach
"Here, we show that voltage- and calcium activated SLO BK potassium channels mediate gap junction signaling to inhibit calcium pathways for asymmetric AWC differentiation."
26771544
reach
"K + exits from the hair cells through the potassium voltage gated channel subfamily Q member 4 (KCNQ4) and the potassium calcium activated channel subfamily M alpha 1 (KCNMA1) channels."
| PMC
reach
"When the Ca 2+ bowl is deleted, the BK channel is still activated by Ca 2+ but with lower affinity."
20508092
reach
"This ATPase is potentially responsible for the difference in the observed higher level of the cytosolic Ca 2+ increase after calcium ionophore stimulation in SLO treated iRBC than that in saponin treated iRBC."
27006284
reach
"Large-conductance calcium activated (maxi-K, BK) potassium channels are widely distributed in the brain."
11496927
reach
"Kcnma1 encodes the alpha subunit of the large conductance calcium-activated potassium BK channel in PCs, and loss-of-function mutations cause ataxia in mice [34]."
38673939
reach
"Considering that [Ca (2+)] (i), which would activate the BK channel, is the key issue in neurodegeneration, it would be suggested by the results from this study that K (+) channel blocker, rather than activator, would potentially present the neuronal protective effect."
29648715
reach
"Among the 13 patches tested in these mutant animals, seven showed SLO-1 channel activity that was inhibited reversibly by the removal of internal Ca 2+ ( Figure 4 (a), lower trace)."
16527307
reach
"Maxi-K activation by [Ca] i plays an important role in setting steady-state [Ca] i ."
16766616
reach
"The present results suggest that in addition to or in conjunction with channels of the Kv3 and Kv1 families, KCa1.1 channels play a crucial role in the fast repolarization of the membrane potential at the end of each spike.The immediate cessation of spiking at the end of photostimulation suggests that the increase in cytosolic calcium resulting from repetitive firing induces KCa1.1 channel activation near resting potential values."
36326690
reach
"This is consistent with Ca 2+ entry through L-type Ca 2+ channels driving BK channel activation and hyperpolarization of the membrane potential."
22830588
reach
"A series of compounds have been reported which open the large conductance calcium activated potassium channel (maxi-K)."
8371147
reach
"BK channel activation by Ca 2+ sparks triggers transient BK currents (TBKCs), also known as spontaneous transient outward currents (STOCs) [XREF_BIBR], which regulate UBSM excitability."
26536038
reach
"To determine what proportion of the non inactivating outward current is carried by SLO potassium currents, we examined the effect of extracellular Ca 2+ on outward currents in dilp2-neurons, since the SLO channel is highly activated by intracellular Ca 2+ that enters through Ca 2+ channels."
22532808
reach
"The guanylate kinase domain of Ca (v) beta1 mediates Slo1 regulation through its binding to calcium bowl domains, and this domain of Ca (v) beta1 is necessary and sufficient for the observed effects on BK (Ca) activation."
17989350
reach
"In this study we test the hypothesis that the steroid hormone ecdysone regulates gene expression of the voltage gated calcium activated potassium ion channel, Slowpoke or KCNMA1."
20669322
reach
"Since slo-2 encodes the only other calcium activated SLO like potassium channel in C. elegans and its expression overlaps with slo-1 [XREF_BIBR, XREF_BIBR, XREF_BIBR], we hypothesized that slo-1 and slo-2 may function redundantly to control AWC asymmetry."
26771544
reach
"The mode of action of cyclooctadepsipeptides is only partially understood, but involves the latrophilin Lat-1 receptor and the voltage- and calcium activated potassium channel Slo-1."
25521608
reach
"Charybdotoxin is known to block calcium activated K Ca1.1, MaxiK or BK channels XREF_BIBR, K Ca3.1 or intermediate channels XREF_BIBR and voltage dependent K v1.3 shaker current XREF_BIBR."
25265278
reach
"The obtained results indicated that intracellular Ca ++ chelation with BAPTA abolished the inhibitory effect of BK channel activation on RD.."
29740284
reach
"These results indicate that the voltage dependence of a BK channel activated by Ca 2+ is indistinguishable from that activated by Sr 2+ as long as equipotent concentrations of Ca 2+ and Sr 2+ are used to activate the channel to a similar degree."
9450948
reach
"The distributions of open and shut times were calculated to further examine the difference in the gating of the BK channel activated by Ca 2+ and Sr 2+."
9450948
reach
"Other members of this gene family include BK (Slo1) channels, which are activated by cytosolic Ca 2+ instead of Na +, as well as a host of orthologues found in prokaryotes, such as MthK (Rothberg & Magleby, 2000; Jiang etal."
28261807
reach
"Thus, coupling can potentially be mediated by state-dependent interactions at interfaces between moving parts of sensor and PGD, as proposed for the canonical electromechanical mechanism, or by covalent linkers that connect such domains, as previously proposed for the Ca -dependent activation of Slo1 (24)."
36516264
reach
"These prokaryotic channel structures inspired a series of mutational studies demonstrating that the RCK1 and RCK2 domains in mouse Slo1 (mSlo1) account for the Ca -dependent activation of mSlo1 [9,10,11,12,13], and provided templates for the generation of homology models of the mSlo1 channel gating ring: the four RCK1 and four RCK2 domains from the four subunits in a functional Slo1 channel form a “gating ring”."
36005673
reach
"Since SLO-1 colocalizes with the L-type voltage gated Ca 2+ channel EGL-19 and EGL-19 is the predominant voltage gated Ca 2+ channel in body-wall muscle, SLO-1 could potentially be activated by Ca 2+ entering through EGL-19 and, in turn, regulate intracellular [Ca 2+]."
22131396
reach
"A maxi K channel with a single-channel conductance of 132 pS (105 mM K on both sides of the membrane, 15 degrees C) is activated both by micromolar concentrations of internal Ca and by depolarization."
2041727
reach
"Thus, SloTx is a more reliable pharmacological tool than ChTx or IbTx to distinguish channels formed by MaxiK alpha+ beta4 complexes.The toxin specificity was assayed in different types of K + channel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11576530
reach
"Mannowetz et al. proposed that Slo1 is the main K channel in human sperm, as the Slo1 channel is activated by Ca ."
34744797
reach
"The increase in intracellular Ca concentration or the change in voltage activates the BK channel so that the intracellular K flows out through the pore of the channel composed of the α subunit, thereby dilating blood vessels and maintaining a balance of vascular tension [14]."
36514218
reach
"Increased dietary K intake leads to a marked upregulation of renal TRPV4 expression and activity to facilitate flow‐induced K secretion via large conductance Ca activated BK channel in the collecting duct (Mamenko et al., 2017)."
36946001
reach
"The Ca 2+ -permeable, nonselective cation channel TRPV4 may act here as a flow sensor to activate the BK channel ( Stavniichuk et al., 2023 )."
37454737
reach
"Interestingly, thalidomide elevated big- or large-conductance, calcium activated K + (BK) channel expression in the plasma membrane and BK channel activity in the hippocampus."
30518785
reach
"BK channel activation can be induced by Ca 2+ influx through L-type channels, P/Q-type channels, N-type channels, and NMDAR but not R-type Ca v 2.3 Ca 2+ channels."
19342611
reach
"Together the results identify a novel Cav3-KCa1.1 signaling complex where Cav3 mediated calcium entry enables KCa1.1 activation over a wide range of membrane potentials according to the unique voltage profile of Cav3 calcium channels, greatly extending the roles for KCa1.1 potassium channels in controlling membrane excitability."
23626738
reach
"Specific primers for QRT-PCR for MR (nuclear receptor subfamily 3, group C, member 2; Nr3c2), BKCaalpha1 (potassium large conductance calcium activated channel, subfamily M, alpha member 1; Kcnma1), BKCabeta1 (potassium large conductance calcium activated channel, subfamily M, beta member 1; Kcnmb1), Cav1.2 (calcium channel, voltage dependent, L type, alpha 1C subunit; Cacna1c) and B2m are listed in XREF_SUPPLEMENTARY."
22922412
reach
"The calcium influx required to activate KCa1.1 channels can derive from high voltage activated (HVA) calcium channel conductance by virtue of a molecular association between KCa1.1 and HVA calcium channels XREF_BIBR, XREF_BIBR - XREF_BIBR."
23626738
reach
"Binding of the intracellular Ca 2+ at the CTD enhances the BK channel opening."
29751615
reach
"KCNMA1 encodes for the alpha subunit of the large conductance calcium-activated potassium channel (BK channel; also known as Slo), and its alternative splicing has been suggested to be important for frequency tuning along the tonotopic axis by influencing the channel gating properties (Navaratnam et al., 1997; Rosenblatt et al., 1997; Frucht et al., 2011)."
34568429
reach
"BK channel has large single-channel conductance (often> 200 pS), and is activated by membrane depolarization and elevation of cytoplasmic free [Ca 2+]."
18759010
reach
"In sympathetic neurons of rat superior cervical ganglia, blocking either BK channels with charybdotoxin or L-type Ca 2+ channels with nifedipine increases the half-width of action potentials whereas blocking other VSCCs has no such effect, suggesting that Ca 2+ entry via L-type channels selectively activates the BK channel [XREF_BIBR]."
18759010
reach
"When cells that have been permeabilized with streptolysin-O (SLO) were treated with either 10 muM Ca 2+ / 3 mM ATP or < = 100 muM GTPgammaS/1 mM ATP and cytosol (from rat brain) -- conditions that ind[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12217404
reach
"In rat cerebellar Purkinje neurons, blocking P/Q-type Ca 2+ channels suppresses afterhyperpolarization [XREF_BIBR], which is mainly contributed by the BK channel [XREF_BIBR], suggesting that Ca 2+ entry via P/Q-type channels may activate the BK channel."
18759010
reach
"The diversity of Ca 2+ channels that may mediate BK channel activation suggests that activation of BK channels by colocalized Ca 2+ channels is not a unique property of a specific type of VSCC; rather, the apparent specificity of coupling reflects the identity of VSCCs that are coexpressed and colocalized with the BK channel."
18759010
reach
"Voltage- and Ca 2+ -dependent activation of Slo1 was negatively correlated with the C-linker length."
29025867
reach
"Maxi-K + channels of both, HO-2 +/+ and -/- glomus cells, were modulated by intracellular Ca 2+ (XREF_FIG), and single-channel current amplitude and slope single-channel conductance were similar in the two animal types (XREF_FIG)."
16966473
reach
"To further test whether calcium influx through Cav3.2 channels could provide a sufficient increase of [Ca] i to mediate a shift in KCa1.1 voltage dependence, cells were held at -100 mV and stepped to voltages ranging from -70 to +40 mV in the presence or absence of coexpressed Cav3.2 channels."
23626738
reach
"Activation of Slo1 by Ca 2+ Is Potentiated by Internal Mg 2+."
11696615
reach
"We further examined the time course of KCa1.1 activation by Cav3.2-mediated calcium influx by increasing the amount of time between the Cav3.2 prepulse to -30 mV and the P2 step."
23626738
reach
"We then used patch clamp recordings in in vitro tissue slices from P12-P16 rats to examine if Cav3 calcium influx is sufficient to activate KCa1.1 in MVN cells."
23626738
reach
"BK channel currents activated by Ca sparks provide critical negative feedback regulation that limits the magnitude and duration of cerebral artery constriction (15, 25)."
31591206
reach
"Ca influx through TRPV4 channels signaled through RyR–BK channel to induce SMC hyperpolarization and vasodilation [30]."
34560190
reach
"Knockdown of JPH2 expression had no effect on SR Ca store load or Ca uptake, the frequency of spontaneous Ca sparks, or the amplitude and kinetics of individual events, but nearly eliminated transient BK channel currents activated by Ca sparks, demonstrating that JPH2 is necessary for functional coupling of BK channels on the plasma membrane and RyR2s on the SR."
31591206
reach
"The large-conductance Ca 2+ - and voltage activated K + (MaxiK, BK, BK Ca, Slo1, K Ca 1.1) channel role in cell signalling is becoming apparent as we learn how the channel interacts with a multiplicity of proteins not only at the plasma membrane but in intracellular organelles including the endoplasmic reticulum, nucleus and mitochondria."
24077696
reach
"During muscarinic signaling, BK channels assume a greater role due to the depolarized membrane potential and elevated calcium that support BK channel activation."
24109455
reach
"These studies did not examine the possibility that activation of ASIC1a, and subsequent Na -dependent depolarization and/or Ca influx, elicits BK channel activity."
36484717
reach
"Stimulation of intracellular calcium via L-type calcium channels increases BK channel activity, which leads to compensatory closure of L-type calcium channels and vasodilation ( Joseph et al., 2013 )."
25481230
reach
"In fact, it has been previously observed that the functional disruption of the calcium bowl does not disrupt BK channel regulation produced by Cd 2+, leading to the suggestion that the BK channel may contain additional Ca 2+ regulatory sites."
15738049
reach
"All experiments on pulmonary arterial myocyte potassium currents were recorded in the presence of paxilline (1 µmol/L), in order to block the large conductance voltage- and calcium-activated potassium channel (KCa1.1)."
36028487
reach
"The voltage gated L-type calcium channel and the functionally linked calcium activated BK channel represent a functional dyad."
12065764
reach
"Together these results confirm that Cav3 mediated calcium influx can activate KCa1.1 current in the low voltage range of ~ -50 mV, well below that of most voltage gated potassium channels that activate above -40 mV XREF_BIBR."
23626738
reach
"Previous work indicates that specific isoforms of HVA calcium channels can activate KCa1.1 channels to contribute to spike repolarization and generating AHPs XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR."
23626738
reach
"It is clear that the aminophenylamidines are agonists of acetylcholine receptors and have a very similar mode of action as levamisole XREF_BIBR, XREF_BIBR whereas several targets have been suggested for the cyclooctadepsipeptides with the voltage gated, calcium activated potassium channel SLO-1 as most important candidate XREF_BIBR, XREF_BIBR, XREF_BIBR."
24587460
reach
"In contrast, for channels in which the D362 and D367 site alone is mutated, increases in [Ca 2+] from 0 to 300 muM produce only a small slowing of deactivation in marked contrast to wild-type Slo1 (compare XREF_FIG A with XREF_FIG C)."
15738049
reach
"This process involves stimulation of calcium activated large conductance maxi-K (BK) channels in the distal nephron, namely the connecting tubule and the collecting duct."
28187982
reach
"In MVN cells Cav3 calcium influx activated KCa1.1 current from as low as -70 mV for ramp stimuli as well as during square wave steps from -100 mV to +40 mV, and that these were sensitive to block by low concentrations of mibefradil or Ni 2+."
23626738
reach
"The assay is optimized to drive BK channel activation by elevation of intracellular free calcium that peaks approximately 40 s following ionomycin addition before declining (22)."
32913120
reach
"The Slo1 channel is activated by both voltage and intracellular Ca 2+ while the IK and SK channels are gated by intracellular Ca 2+ alone."
29948841
reach
"Emodepside acts on the calcium-activated potassium channel (SLO-1) and latrophilin receptor (LAT-1) of nematodes, inhibiting pharyngeal pumping, paralysis, and death."
39827513
reach
"We also speculate that potassium channels with inherent noisy current with PSDs following a distribution in the relevant frequency range, underlie the observed high-frequency power laws, and the slow voltage- and calcium activated BK channel, reported to have a very large channel conductance XREF_BIBR, is suggested as a main contributor XREF_BIBR."
25393030
reach
"However, given the data we present in this report (especially XREF_FIG and XREF_FIG), the calcium concentrations in ischemic neurons should be sufficient to allow a strong potentiation of BK channel activity in CNS neurons and hyperpolarization of the ischemic neurons, reducing excitatory amino acid release, and reducing ischemic calcium entry."
26277265
reach
"Large conductance (G), Ca , and voltage-activated potassium channels (BK, MaxiK, or KCa1.1) are allosterically activated by an increase in intracellular calcium and depolarization (1, 2)."
36738787
reach
"We analyzed transcript levels in the dataset; the acid sensing potassium channel (TASK-2), epithelial sodium channel (ENaC) and Ca 2+ activated chloride channel were all decreased (anoctamin-1, TMEM16), whereas Ca 2+ activated potassium channels (KCa3.1, " SK " and KCa1.1, " BK ") and aquaporin 1 (AQP1) were strongly up-regulated."
26648874
reach
"Among the diverse family of K + channels, large-conductance, calcium activated K + (Maxi-K, also known as BK Ca) channels are the predominant K + channels in myometrium, and thus have been implicated in the control of cellular excitability [XREF_BIBR]."
15383146
reach
"In tsA-201 cells a single pulse from -100 mV to +40 mV recruited very little KCa1.1 current while in MVN cells a step of this size consistently recruited sufficient Cav3 calcium current to activate KCa1.1 channels."
23626738
reach
"Furthermore, a transient Ca 2+ entry through Cav3.2 channels is able to induce a persistent BK channel activation."
24143281
reach
"Several calcium sources could potentially regulate BK channel activity."
29348160
reach
"The same results were observed in SLO permeabilized sperm, where exocytosis was directly triggered by a free calcium rise in the incubation medium (Figs. 1 D-E)."
16099449
reach
"BK channel activation by Ca 2+ sparks was recorded using perforated patch electrophysiology to record spontaneous transient outward currents (STOCs)."
35557207
reach
"However, K ATP channel activator have an action to heart function, we have an idea as needing to target to specific inhabiting receptor on central nervous system such as large-conductance calcium-acti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31805298
reach
"Focal adhesion kinase (pp125FAK) interacts with the large conductance calcium-activated hSlo K + channel (BK) in the focal adhesion complexes of human osteoblasts [6] ."
16930556
reach
"While both compounds exerted practically no effect on the neuronal Nav1.2 and the skeletal muscle Nav1.4 channel or Kv channels from the Kv4, Kv7, Kv11, or KCa2 (SK) family, they exhibited only moderate selectivity over Kv1, Kv2, Kv3 family channels, Kv11.1 (hERG), and the calcium activated K + channels KCa1.1 and KCa3.1."
22685432
reach
"Focal adhesion kinase pp125FAK interacts with the large conductance calcium activated hSlo potassium channel in human osteoblasts : potential role in mechanotransduction."
14584897
reach
"In the vasculature, the most important K+ channel subclasses that are involved in the action of various endothelium derived relaxing factors are the ATP sensitive KATP channel and the large conductance calcium activated BK channel."
21499479
reach
"Furthermore, the reported proximal clustering of Ca 1.3 and BK channels promotes the activation of the BK channel at low voltage and therefore may serve to regulate neuronal excitability in the rat hippocampus (19)."
35914168
reach
"The Slack and Slo channels have intermediate conductances of about 60-180 pS and are activated by cytoplasmic calcium."
10196543
reach
"We have shown that BK channel activation, driven by Ca 2+ influx at single synaptic terminals, serves to constrain the AP broadening occurring during spike trains."
29978045
reach
"Cytosolic calcium would thereafter stimulate the calcium-activated potassium channel BK Slo1 (KCa1.1), inducing potassium leakage to the extracellular space and hyperpolarizing the cell membrane.Furthermore, we considered that only the metalloporphyrin derivatives would interact with the heme-binding motif of Slo1 and partly counteract membrane hyperpolarization by blocking the calcium-dependent activation of Slo1 at 5 µM concentrations."
36838628
reach
"Large conductance calcium- and voltage dependent BK potassium channels (aka BK Ca, MaxiK, Slo1, KCa1.1, and KCNMA1) are expressed in a wide variety of tissues throughout the body and are activated by both intracellular Ca 2+ and membrane depolarization."
23183698
reach
"We next measured BK channel currents activated by Ca sparks (STOCs) in aged and D + Q‐treated VSMCs."
37837625
reach
"Elevation of intra-cellular Ca 2+ from the sarcoplasmic reticulum opens L-type Ca 2+ channels (LTCCs); in turn this increased calcium level activates MaxiK channels leading to relaxation."
25076912
reach
"CRBN is a substrate receptor for the Cul4A and B-DDB 1 ubiquitin ligase (CRL4) and can target voltage- and calcium activated BK channel for ER retention."
29370161
reach
"Nevertheless, protein expression of the small conductance calcium-activated potassium channel (SK3) and of the big conductance calcium-activated potassium channel (maxiK) decreased in SHR mesenteric a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29604271
reach
"The biophysical mechanism of BK channel activation by voltage and Ca 2+ can be described by a well established allosteric gating model, in which the channel pore opening is allosterically regulated by the movement of each voltage sensor and the binding of Ca 2+ at each Ca 2+ sensor on the four subunits in a largely independent manner XREF_BIBR, XREF_BIBR."
29323236
reach
"Increases in intracellular Ca 2+ caused by A23187 shift the voltage-dependence of BK channel activation to more negative potentials and thus allow channel opening at the resting membrane potential."
24315877
reach
"Comparisons of the BK channel structures in the absence and presence of Ca 2+ indicate that the gating ring expands in response to Ca 2+ binding and propagates conformational changes to the channel pore XREF_BIBR, XREF_BIBR, suggesting a likely involvement of the interfaces between the RCK domains of adjacent subunits, known as the " intersubunit assembly interface " XREF_BIBR, XREF_BIBR, in BK channel activation by Ca 2+."
29323236
reach
"A major determinant of its anthelmintic effect is the calcium activated potassium channel SLO-1."
21415309
reach
"BK channel activity is initiated by depolarization and enhanced by the simultaneous increase in free intracellular calcium (Ca 2+) concentration."
23785316
reach
"BK channel activation by voltage and Ca 2+ can be well described by the HA allosteric model."
32597752
reach
"Previous studies have shown that MaxiK channels are activated by the release of Ca 2+ from sarcoplasmic reticulum (SR) stores."
19170178
reach
"Interestingly, reducing agents decrease the activity of the large-conductance, calcium-activated potassium channels (BK, also BK , Slo, or MaxiK) and the ROS-induced effects are largely concentration- and tissue-type-dependent [79]."
39171662
reach
"It has often been reported that Ca 2+ and Mg 2+ not only activate MaxiK channels but also block at millimolar concentrations."
17591987
reach
"From these biophysical properties as well as the pharmacological profile, human KSper seems to resemble the calcium-activated big conductance potassium channel Slo1 ( KCNMA1 ) [20] ."
25465894
reach
"The slowpoke (Slo) channel (Also known as large-conductance calcium-activated potassium channel, KCNMA or BK) is synergistically activated by a positive transmembrane potential and high intracellular [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38582588
reach
"The KvAP channel is from the thermophilic archaebacteria Aeropyrum pernix while the HsapBK channel is the Human calcium and voltage-activated BK channel."
19595987
reach
"KCa1.1 channels could be activated by Ca , membrane potential or membrane stretch ."
38849624
reach
"For example,> 500 isoforms of the calcium activated potassium channel Slo that are translated from the different mRNAs produced by the alternative splicing of a single slo gene define the ability of ears to detect a remarkable range of frequencies."
23638354
reach
"Despite the functional simplicity of the BK channel, which is activated principally (for the purpose of this Commentary) by cytoplasmic Ca 2+ and depolarization, and our high level of understanding of the mechanisms underlying its activation, there are still many intricacies of this channel that are not well understood."
18955591
reach
"Hence, increase in the membrane potential or intracellular Ca 2+ concentration can trigger the opening of the BK channel by mediating transient K + outward current in a negative regulatory manner."
31008478
reach
"Therefore, we speculated that changes in Ca or membrane stretching induced by influenza virus binding may activate KCa1.1 and thus regulate F-actin polymerization."
38849624
reach
"Mutations in KCNMA1 increase Ca 2+ sensitivity of the channel by three- to five-fold, resulting in generalized epilepsy and paroxysmal dyskinesia [XREF_BIBR]."
33333793
reach
"Several of these genes are required for extended egl-30(gf) memory, including slo-1/Kcnma1, the α subunit of a calcium-activated BK channel; madd-4/Adamtsl1, which is involved in axon guidance and synapse organization; unc-73/Kalrn, a known downstream target of G signaling, and magi-1/Magi2, a membrane-associated guanylate kinase homolog (MAGUK) family member involved in habituation and long-term memory."
37713310
reach
"Therefore, BK channel itself did not generate [Ca 2+] i oscillation but was modulated by [Ca 2+] i oscillations.In this study, we demonstrated [Ca 2+] i dynamics in isolated single human mesenchymal s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810056
reach
"Additionally, tebufenozide did not significantly accelerate the inactivation rate of the PxSlo ΔE channel under depolarization conditions of 60 mV.In insects, the Slo channel is activated by a positiv[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38582588
reach
"In addition, there were many transcripts related to salivary secretion, such as salivary gland secretion 1 and salivary gland secretion 3, Na-K-Cl cotransporter (NKCC1) and calcium activated potassium[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23434629
reach
"This potential was chosen because most of the single channel modeling concerning the Ca 2+ modulation of BK channel kinetics was done at +30 mV, and this also gives a suitable signal/noise ratio for t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19450470
reach
"These [Ca 2+] i oscillations modulated the activities of a 170 pS Ca 2+ -activated K + channel, which produced the fluctuation of membrane potential."
12810056
reach
"A recent report also shows that a non selective cation channel activated by [Ca 2+] i produces the membrane depolarization to reduce Ca 2+ entry through I SOCs [34,36]."
12810056
reach
"Interestingly, the apparent Hill coefficient for inhibition by proton appears to be only slightly voltage dependent, (XREF_FIG), in contrast to the voltage dependence for activation of Slo1 by Ca 2+ or Mg 2+."
16940555