IndraLab

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OTUB2 activates pathway. 6 / 6
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"Perhaps OTUB2 can activate the Akt pathway on its own without requiring KRT80?"
35110531
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"Besides that, OTUB2 activates the Akt pathway, suggesting that it may be a novel therapeutic and prognostic target in GC."
35110531
sparser
"MKN45 cells express a high level of OTUB2 but very little Ki67 and p-Akt (Thr308), indicating that OTUB2 does not activate the Akt pathway on its own, but via KRT80."
35110531
sparser
"The researchers also investigated the relationship between OTUB2 and KRT80 and the AKT pathway and found that both OTUB2 and KRT80 can activate the AKT pathway."
37211956
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"In conclusion, KRT80 is deubiquitinated by OTUB2, which activates the PI3K/AKT pathway that promotes gastric cancer cell proliferation and growth; KRT80 is essential in this process (Figure  xref ). xref Correlation analysis in 90 GC patients showed that high OTUB2 expression levels were positively correlated with tumor T stage, AJCC stage, and degree of differentiation."
37211956
sparser
"As mentioned above, OTUB2 can stably activate the NF-kappaB pathway through K48 type deubiquitination of TRAF6 and maintenance of phosphorylated p65, resulting in pathological manifestations of cancer."
35309903