IndraLab

Statements

COPS5 activates helicase. 4 / 4
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reach
"The EF-2-like GTPase Snu114 regulates Brr2 activity in a nucleotide dependent manner [XREF_BIBR] while the Jab1 and MPN domain strongly stimulates Brr2 helicase activity in vitro [XREF_BIBR]."
24480332
reach
"When the C-terminal tail of the hPRPF8 Jab1/MPN domain extends into the RNA-binding tunnel of hBRR2, the domain acts as an inhibitor of the helicase; when the tail is removed, the hPRPF8 Jab1/MPN domain activates hBRR2 helicase activity, an effect that can be mimicked by a C-terminally truncated version of the domain (residues 2064–2320; hJab1 ; Mozaffari-Jovin et al., 2013 ▸)."
36974964
reach
"While the entire Jab1 and MPN domain stimulates SNRNP200 helicase activity, XREF_BIBR the C-terminal tail is inserted into the active site of the SNRNP200 helicase and sterically inhibits its activity."
27302685
reach
"Mutational data initially indicated that the interaction of Prp8 Jab1/MPN with Brr2 was repressive to Brr2 activity (Kuhn et al. 2002), though later biochemical evidence showed that the Jab1/MPN domain in fact activates Brr2 helicase activity (Pena et al. 2007; Maeder et al. 2009) while repressing futile ATPase cycling (Maeder et al. 2009) to make Brr2 a more efficient enzyme."
26968627