IndraLab

Statements

CD63 binds ITGB1. 19 / 23
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"Similarly, TIMP-1 has also been reported to regulate cell survival through a signaling complex with integrin beta1 and the tetraspannin CD63 ( Jung et al., 2006 )."
17555826
reach
"It is now well-established that ITGB1 can form a complex with CD63 and with the tissue inhibitor of metalloproteinase-1 (TIMP-1), whereby TIMP-1 binds directly to CD63 [22]."
36291767
reach
"Hence, a CAF-CM-induced increase in the extracellular TIMP-1 level does not necessarily result in activating the CD63/ITGB1 complex to activate STAT3 or ERK1/2."
36291767
reach
"Our data suggest that STAT3 can be activated by a cooperative interaction of TIMP-1, CD63 and ITGB1."
36291767
sparser
"An siRNA targeting CD63 (siCD63) and an siRNA directed against ITGB1 (siITGB1) showed similar effects as siTIMP1, suggesting that, in AnD5 cells, TIMP-1 regulates STAT3 and ERK1/2 activities by forming a complex with CD63 and ITGB1."
36291767
reach
"For example, TIMP-1 promotes cell survival in erythroleukemic cells after binding with a CD44 and proMMP -9 complex receptor [XREF_BIBR, XREF_BIBR] and in breast and lung epithelial cells after interacting with a CD63 and integrin-beta 1 complex receptor [XREF_BIBR, XREF_BIBR]."
23936774
reach
"In another study, it was discovered that TIMP1 interacts with the CD63/ITGB1 complex, leading to the activation of downstream FAK signaling."
38961424
reach
"These findings imply that the interaction between TIMP1 and ITGB1/CD63 may contribute to maintaining the integrity of the blood-brain barrier, which is vital for neuroprotection [82]."
38961424
biogrid
No evidence text available
24635319
biogrid
No evidence text available
24635319
sparser
"We also transfected cells with siCD63 and siITGB1 to explore the possibility that TIMP-1 stimulates its own expression by forming a complex with CD63 and ITGB1."
36291767
sparser
"A study by Takawale A. et al. also showed that TIMP-1 is involved in inducing myocardial fibrosis, independently of its function of inhibiting MMPs by mediating the interaction between fibroblast membrane proteins and the CD63 receptor and β1 integrin."
37893149
biogrid
No evidence text available
12175627
sparser
"Melanoma cells have been shown to produce TIMP1, which helps them overcome apoptosis by building complexes with CD63 and ITGB1 [ xref ]."
38279122
sparser
"In cardiac fibroblasts, crosstalk between β1 integrin and Platelet-Derived Growth Factor Receptor (PDGFR)-β was found to activate a proliferative response [ 76 ], whereas an interaction between β1 int[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35872324
sparser
"It is now well-established that ITGB1 can form a complex with CD63 and with the tissue inhibitor of metalloproteinase-1 (TIMP-1), whereby TIMP-1 binds directly to CD63 [ xref ]."
36291767
sparser
"On the other hand, in premalignant melanocyte Melan-a cells, overexpression of TIMP-1 is associated with poor prognosis by binding to CD63 and β1 integrin."
36067841
sparser
"In relation to apoptosis recent studies have suggested that TIMP-1 could be associated with resistance to chemotherapy-induced apoptosis in cancer cells ( Davidsen et al., 2006; Schrohl et al., 2006; [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19383344
trips
"Ameloblastin bound to CD63 and promoted CD63 binding to integrin β1."
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