IndraLab

Statements

CD63 binds ITGB1. 16 / 23
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"A study by Takawale A. et al. also showed that TIMP-1 is involved in inducing myocardial fibrosis, independently of its function of inhibiting MMPs by mediating the interaction between fibroblast membrane proteins and the CD63 receptor and β1 integrin."
37893149
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"Similarly, TIMP-1 has also been reported to regulate cell survival through a signaling complex with integrin beta1 and the tetraspannin CD63 ( Jung et al., 2006 )."
17555826
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"It is now well-established that ITGB1 can form a complex with CD63 and with the tissue inhibitor of metalloproteinase-1 (TIMP-1), whereby TIMP-1 binds directly to CD63 [22]."
36291767
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"Hence, a CAF-CM-induced increase in the extracellular TIMP-1 level does not necessarily result in activating the CD63/ITGB1 complex to activate STAT3 or ERK1/2."
36291767
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"Our data suggest that STAT3 can be activated by a cooperative interaction of TIMP-1, CD63 and ITGB1."
36291767
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"An siRNA targeting CD63 (siCD63) and an siRNA directed against ITGB1 (siITGB1) showed similar effects as siTIMP1, suggesting that, in AnD5 cells, TIMP-1 regulates STAT3 and ERK1/2 activities by forming a complex with CD63 and ITGB1."
36291767
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"For example, TIMP-1 promotes cell survival in erythroleukemic cells after binding with a CD44 and proMMP -9 complex receptor [XREF_BIBR, XREF_BIBR] and in breast and lung epithelial cells after interacting with a CD63 and integrin-beta 1 complex receptor [XREF_BIBR, XREF_BIBR]."
23936774
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"In another study, it was discovered that TIMP1 interacts with the CD63/ITGB1 complex, leading to the activation of downstream FAK signaling."
38961424
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"These findings imply that the interaction between TIMP1 and ITGB1/CD63 may contribute to maintaining the integrity of the blood-brain barrier, which is vital for neuroprotection [82]."
38961424
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"We also transfected cells with siCD63 and siITGB1 to explore the possibility that TIMP-1 stimulates its own expression by forming a complex with CD63 and ITGB1."
36291767
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"Melanoma cells have been shown to produce TIMP1, which helps them overcome apoptosis by building complexes with CD63 and ITGB1 [ xref ]."
38279122
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"In cardiac fibroblasts, crosstalk between β1 integrin and Platelet-Derived Growth Factor Receptor (PDGFR)-β was found to activate a proliferative response [ 76 ], whereas an interaction between β1 int[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35872324
sparser
"It is now well-established that ITGB1 can form a complex with CD63 and with the tissue inhibitor of metalloproteinase-1 (TIMP-1), whereby TIMP-1 binds directly to CD63 [ xref ]."
36291767
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"On the other hand, in premalignant melanocyte Melan-a cells, overexpression of TIMP-1 is associated with poor prognosis by binding to CD63 and β1 integrin."
36067841
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"In relation to apoptosis recent studies have suggested that TIMP-1 could be associated with resistance to chemotherapy-induced apoptosis in cancer cells ( Davidsen et al., 2006; Schrohl et al., 2006; [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19383344
trips
"Ameloblastin bound to CD63 and promoted CD63 binding to integrin β1."
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