IndraLab

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OTUB2 decreases the amount of CD274. 2 / 2
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"Western blot analysis of cellular lysates confirmed that OTUB2 KD or KO induced a decrease in the PD-L1 protein level, while OTUB2-WT but not OTUB2-C51S overexpression caused an increase (Fig. 3h, i and Supplementary Fig. 11a−f)."
38167274
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"An inhibitor of OTUB2, interfering with its deubiquitinase activity without disrupting the OTUB2-PD-L1 interaction, successfully reduces PD-L1 expression in tumor cells and suppressed tumor growth."
38167274