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SMURF1 decreases the amount of USP5. 2 / 3
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"Moreover, down-regulation of USP5 expression by Smurf1 was presented in a dose dependent manner."

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"In this study, we identified the HECT-type E3 ligase, Smurf1, could regulate the stability and function of USP5.First of all, we demonstrated that USP5 protein levels could be reduced by Smurf1 in a d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"