IndraLab

Statements

USP18 activates STAT. 4 / 7
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"Ye et al. (2021) demonstrated that DENV-2 infection increased USP18 expression; USP18 overexpression enhanced DENV-2 replication, while USP18 silencing inhibited DENV-2 replication by activating the IFN-α-mediated JAK/STAT signaling pathway."
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"USP18, a protein of 368 aa in length and an ISG15 isopeptidase, is a negative regulator of type I and III IFN-activated JAK/STAT signaling [142], and is rapidly upregulated by viral infection and IFNs."
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"By inhibiting the JAK/STAT pathway and suppressing the downstream effects of type I IFN signaling USP18 effectively reduces auto-inflammatory pathogenesis."
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"In contrast, silencing USP18 activates the Jak and STAT signaling and potentiates IFN anti-HCV ativity [XREF_BIBR]."
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