IndraLab

Statements

IFNs activates USP18. 5 / 5
| 5
reach
"Although CXCL10, STAT1, PSMB8 and USP18 (Figure 6A, grey) were induced by all IFNs, pathway analysis revealed uniquely regulated genes, specifically by each member of the IFN family (Figure 6)."
36354438
reach
"USP18, a protein of 368 aa in length and an ISG15 isopeptidase, is a negative regulator of type I and III IFN-activated JAK/STAT signaling [142], and is rapidly upregulated by viral infection and IFNs."
29662014
reach
"However, SOCS1, SOCS3 and USP18 function as part of a negative feedback loop induced by IFNs to limit the extent and duration of type-I IFN responses."
35545202
reach
"USP18 is stimulated by IFNs, which form a negative feedback loop and act as isopeptidases for specific substrates with ISG15, a ubiquitin-like protein [41]."
35955709
reach
"It is notable that both USP18 (Supplementary Figures 3 and 4) and KRT2 were differentially expressed upon TNF stimulation in keratinocytes, and USP18 was also upregulated by IFNs."
34343561