IndraLab

Statements

OTUB2 activates cell growth. 6 / 6
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"At the cellular level, knockdown of OTUB2 markedly inhibited liver cancer cell growth."
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"Knockdown of OTUB2 suppressed CC cell growth whereas OTUB2 upregulation fostered the proliferation of cancer cells."
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"Inhibition of OTUB2 suppresses colorectal cancer cell growth by regulating β-Catenin signaling."
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"The results demonstrated that OTUB2 knockdown significantly inhibited TNBC cell growth, while overexpression promoted cell growth in a time-dependent manner (Fig. 3A,B)."
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"Overexpression of OTUB2 enhanced glycolysis and promoted cell growth, migration, and invasion via the AKT/mTOR signaling pathway in A549 and H1299 cells and a xenograft mouse model (Li J. et al., 2019)."
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"Our further investigations revealed that knockdown of OTUB2 significantly suppressed NF-kappaB-driving luciferase activity, and markedly inhibited the phosphorylation of NF-kappaB p65 in liver cancer cells, which indicated that OTUB2 mediated liver cancer cell growth by regulating NF-kappaB signaling."
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