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TNF activates TNFAIP3. 64 / 71
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"Here we evaluate a novel molecular target, A20, also known as tumor necrosis factor alpha-induced protein 3 (TNFAIP3), which may help to block pathological TGFβ2-TLR4 signaling."
35216043
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"MeRIP-sequencing and functional studies confirmed that tumor necrosis factor alpha induced protein 3 (TNFAIP3), a key suppressor of NF-κB inflammatory pathway, was involved in m6A-regulated PBMCs."
37327357
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"We also found that A20 (also known as tumor necrosis factor alpha induced protein 3, or TNFAIP3) protected against CVB3 induced myocarditis by inhibiting inflammatory response."
26269170
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"On the other hand, both untreated (basal level) and TNF-induced activation of the A20 promoter were severely compromised in E1A/Ras MEFs ( xref )."
19826422
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"TNFAIP3 is downstream of TNF signaling pathway and can be induced by TNF ."
36275661
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"Aberrations in TNF signaling were apparent with upregulation of both TNF and TNF receptor superfamily members but universal downregulation of IRF8 bound TNF induced TNFAIP3, a negative regulator of cytokine mediated immune and inflammatory responses."
29128673
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"To test this hypothesis, we targeted A20 (tumor necrosis factor alpha induced protein 3 [TNFAIP3]), an anti-inflammatory molecule and primary negative regulator of NF-kappaB activity."
28683286
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"A20 (Tumor Necrosis Factor alpha-Induced Protein3; TNFAIP3) Deficiency."
31847438
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"A20, which is encoded by Tumor Necrosis Factor α- Induced Protein 3 (TNFAIP3), was initially identified as a primary responsive gene induced by TNF-α ."
32968045
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"TNFAIP3 is known to be rapidly induced by the TNF, and its encoded protein is a zinc finger protein and ubiquitin-editing enzyme ."
32139701
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"55 A testable hypothesis would thus be that combined innate and adaptive stimulation from certain cross-reactive commensals drive chronic autoreactivity in genetically predisposed people such as those carrying certain human leukocyte antigen (HLA) and innate immune variants (e.g. tumor necrosis factor alpha induced protein 3 or TNFAIP3)."
24763536
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"Ungerback et al. showed that variations in tumor necrosis factor alpha–induced protein 3(TNFAIP3), NLRP3 and NFκB genes were related to CRC susceptibility [89]."
30447690
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"In addition, increased expression of IFN inducible transcription factors STAT1 and STAT2, TNF-alpha induced protein TNFAIP3, apoptosis related proteins caspase3 and caspase4, suppressors of cytokine signaling Socs1 and Socs3, pro inflammatory cytokines IL-1 and IL-6, TLR7, as well as IFN response antiviral genes of OAS family were also observed in microarray analysis."
21345237
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"In addition, the tumor necrosis factor, alpha-induced protein 3 (TNFAIP3), is a central regulator of immunopathology and associated with the maintenance of immune homeostasis and severe viral infections (Mérour et al. 2019; )."
| DOI
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"TNF-alpha induces TNFAIP3, tumor necrosis factor-alpha-induced-protein 3 which is also known as A20, TNFAIP3 interacts with TNIP1 gene encoded TNFAIP3 interacting protein 1 (TNIP1 protein), TNFAIP3 and TNIP1 then in conjunction regulate NF-kappaB dependent gene expression negatively."
33889172
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"Accordingly, we tested the recruitment of A20 proteins to TNFR immunoprecipitates in TNF stimulated Tnfaip3 OTU and ZF4, Tnfaip3 ZF4 and ZF4, and Tnfaip3 OTU and OTU cells."
23602765
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"Accumulating studies have revealed the involvement of tumor necrosis factor alpha-induced protein 3 (TNFAIP3) in the progression of AP."
34481142
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"Whole exome sequencing revealed a heterozygous splice site variant c.1907-5T > G in tumor necrosis factor alpha-induced protein 3 (TNFAIP3/A20)."
28188499
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"To further characterize the mechanism by which TNF activates the A20 gene, we have cloned the A20 5'-flanking sequences and identified TNF-responsive elements within the promoter."
1381359
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"Tumor necrosis factor alpha induced protein 3 gene (TNFAIP3, also called A20) haploinsufficiency (HA20) leads to autoinflammation and autoimmunity."
31977656
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"A20 (tumor necrosis factor alpha induced protein 3 or TNFAIP3) is a ubiquitin editing enzyme that mainly functions as an endogenous regulator of inflammation through termination of nuclear factor (NF)-kappaB activation as part of a negative feedback loop."
32853526
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"TNFAIP3, a gene important in cytokine mediated immune and inflammatory responses, is induced by TNF, another c-Fos target gene."
28465464
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"Additionally, several deubiquitination enzymes (DUBs), including A20 (also known as tumor necrosis factor alpha induced protein 3; TNFAIP3) and the tumour suppressor, CYLD (also known as cylindromatosis), implicated in familial cylindromas, have been shown to control critical signalling steps upstream of the IKK complex [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"This result was also substantiated by studies of the role of IKKα and IKKβ on either IL-1 or TNFα activation of the A20 gene."
12547194
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"First, TNFAIP3 (tumor necrosis factor alpha induced protein 3) localized in the nucleus, is rapidly induced by Tumor Necrosis Factor (TNF), and is critical for limiting inflammation by terminating TNF induced NF-kappa B responses as well as TNF mediated apoptosis."
19936255
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"ICAM1, TNFAIP3, ALDR1 and PAI2 were reported to be induced by TNF stimulation of synoviocytes [12], endothelial cells [13], liver cells [14] and melanoma [12], respectively."
12062421
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"Tumor necrosis factor alpha induced protein-3 (TNFAIP3) encodes ubiquitin modifying protein A20 and has a critical role in the regulation of immune signaling pathways."
26106387
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"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR Tumor necrosis factor alpha induced protein 3 (TNFAIP3, also known as A20), functioning as an ubiquitin editing enzyme, 15 negatively regulates NF-kappaB signaling through dual mechanisms, that is, deconjugation of K63 linked polyubiquitin chains from RIP-1 and subsequent conjugation of RIP-1 with K48 linked polyubiquitin chains for proteasomal degradation."
28569771
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"Activating mutations that target the genes encoding the BCR subunits CD79a and CD79b, the BCR pathway adaptor caspase recruitment domain family member 11 (CARD11), and MYD88 promote NF-κB activity in ABC DLBCL, as do genetic and epigenetic events that inactivate tumor necrosis factor α–induced protein 3 (TNFAIP3, also known as A20) ."
26193343
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"In upregulated genes induced by IL-1β, treatment with STF (3 μg/mL) provided greater effects on downregulation of inflammatory and immune genes involved in NF-κB components (NFKB1,NFKBIA,NFKBIZ), chemokines (CCL2,CXCL1,CXCL2,IL8), transcriptional regulator (IRF1), prostaglandin E synthase (PTGES) and TNF alpha induced protein family (TNFAIP2, TNFAIP3, TNFAIP6) than indomethacin in IL-1β-treated cells."
28068976
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"To introduce new diagnostic markers in patients with celiac disease for easy, fast, low cost, and non-invasive diagnosis, we evaluated the peripheral blood expression levels of interleukin-15 (IL-15), interleukin-17A (IL-17A), interleukin23A (IL-23A), granzyme B (GzmB), T-box transcription factor 21 (TBX21), and tumor necrosis factor alpha-induced protein 3 (TNFAIP3) of patients compared with the healthy controls, which were extracted from public databases organized in a protein-protein interaction network, in this group."
36619141
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"Two targets of miR-21 : Interleukin I Beta (IL1beta) and tumor necrosis factor, alpha induced protein 3 (TNFAIP3), which is rapidly induced by the TNF were assayed by RT-qPCR on mRNA in another APP infection study in pigs [XREF_BIBR]."
22953717
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"In addition, reduced expression was also evident for two IL17 target genes in vertebrates : tumor necrosis factor alpha induced protein 3 (tnfaip3; also known as A20), which encodes a ubiquitin editing enzyme that inhibits NF-kappaB activation, and NF-kappaB inhibitor zeta (nfkbiz), an IL17 target gene in vertebrates that also regulates NF-kappaB activity."
29109720
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"Tumor necrosis factor alpha induced protein 3 (TNFAIP3/A20) and TNFAIP3 interacting protein 1 (TNIP1) have been accepted as the related candidate genes for psoriasis (16–18)."
33981308
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"TNFalpha induced protein-3 (TNFAIP3; also known as A20) is a ubiquitin editing enzyme that acts as a negative regulator of NFkappaB."
19849816
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"In another study of 667 AS patients and 667 matched healthy controls, tumor necrosis factor alpha-induced protein 3 (TNFAIP3) conferred a protective effect on AS susceptibility (Yang et al., 2019)."
34746233
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"Expression of TNFAIP3 is increased in PBMC from rheumatoid arthritis (RA) patients, consistent with findings that TNFAIP3 is rapidly induced by TNF, the expression of which is known to be markedly elevated in active RA patients."
28630090
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"It was shown that TNFAIP3 is induced by TNF and IL-1 and might therefore be involved in the regulation of NFkappaB dependent genes in diverse bacterial infections."
28401065
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"Examples of three genes found among the most significantly induced genes including transcription factor ATF3, matrix metallopeptidase MMP13 and TNF alpha induced protein TNFAIP3 were shown (Figure 5E)."
33836152
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"As expected, TNFalpha treatment rapidly induced NF-kappaB activation, reflected by robust expression of NFKBIA (encoding IkappaBalpha) and TNFAIP3 (XREF_SUPPLEMENTARY), two direct downstream targets of NF-kappaB."
30659163
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"NF-kappaB signaling is controlled by negative feedback via IkappaBalpha and A20 and TNIP2 (tumor necrosis factor alpha induced protein 3 [TNFAIP3] in chicken) transcriptional induction [XREF_BIBR] and we found TNFAIP3 mRNA and protein unchanged but IkappaBalpha mRNA decreased, suggesting that this negative feedback mechanism is suppressed."
22979947
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"Tumor necrosis factor alpha induced protein 3 (TNFAIP3), also known as A20, is a ubiquitin editing enzyme with well-known functions regulating inflammatory signaling and cell death downstream of the TNF-receptor superfamily [1]."
29718933
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"This study investigated the potential combined influence of PPARalpha, tumor necrosis factor alpha induced protein 3 (TNFAIP3 and A20), and tumor necrosis factor receptor associated factor 6 (TRAF6) on interleukin (IL)-12p40 production by macrophages exposed to DEHP and stimulated with lipopolysaccharide (LPS)."
28673093
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"Transcriptome analysis and further experimental confirmation in MDA-MD-231 cells revealed that forced overexpression of CTCF might attenuate the DNA binding ability of nuclear factor-kappaB (NF-kappaB) p65 subunit and inhibit activation of NF-kappaB and its target pro oncogenes (tumor necrosis factor alpha induced protein 3 [TNFAIP3]) and genes for growth related proteins (early growth response protein 1 [EGR1] and growth arrest and DNA-damage-inducible alpha [GADD45a])."
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"Nuclear run-on studies previously established that TNF activates A20 at the transcriptional level."
1381359
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"PACAP inhibited TNF-alphainduction of IkappaBalpha mRNA (XREF_FIG), but had no effect on TNF-alpha elevation of TNFAIP3 mRNA (XREF_FIG)."
19647754
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"TNFAIP3, a protein whose expression is rapidly induced by TNF-alpha, is a ubiquitin centered enzyme and has been shown to constrain NF-kappaB activation."
30022124
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"A20, known as tumor necrosis factor alpha‐induced protein 3 (Tnfaip3), is a deubiquitinase enzyme with a crucial function in the inhibition of various proinflammatory molecules, including RIPK1 and IKKγ."
| PMC
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"In a large prospective study of patients with type 1 diabetes in the USA, researchers have reported three SNPs associated with increased risk of type 1 diabetes (rs10517086_A, rs1534422_G and rs2327832_G in tumor necrosis factor, alpha induced protein 3 [TNFAIP3]) and one with decreased risk (rs1004446_A in INS) 43."
29499103
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"TNFAIP3 participates in immune and inflammatory responses signaled by cytokines, such as TNF, and TNFAIP3 is rapidly induced by TNF."
27838757
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"Whereas subsequent budesonide treatment enhanced TNF induced TNFAIP3 and reduced TNF expression, formoterol amplified these differential effects."
28039105
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"TNFalpha acts on NF-kappaB to increase TNFAIP3 gene products."
21497601
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"Additionally, FC-99 inhibited the activation of IkappaB-alpha and upregulated the expression of TNFalpha induced protein 3 (TNFAIP3) in vitro and in vivo."
28342978
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"We showed that Pgp3 induced prominent expression of host inflammatory cytokine genes including interleukin-6 (IL-6), IL-8, tumor necrosis factor alpha-induced protein 3 (TNFAIP3), and chemokine C-X-C motif ligand 1 (CXCL1), implying a possible role of Pgp3 in modulating the inflammatory reaction in the host."
36870960
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"TNFAIP3 expression ( encodes A20 ) is rapidly induced by TNF-alpha ."
30386338
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"TNFAIP3 is induced by TNF and inhibits the NF-kappaB pathway by de-ubiquitination and ubiquitination of the TNF receptor interacting protein XREF_BIBR."
26940175
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"The tumor necrosis factor alpha induced protein-3 (TNFAIP3) gene functions in negative immunoregulation and its single-nucleotide polymorphisms (SNPs) are associated with rheumatoid arthritis (RA) disease."
26405544
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"We previously found that TNFα signaling enhanced TNFAIP3 (tumor necrosis factor-induced protein 3) expression in conventional T cells (20)."
32038615
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"A20 (the tumor necrosis factor alpha-induced protein 3, TNFAIP3) is one of the key regulators of inflammation and cell death in numerous tissues."
35212946
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"In particular, CXCR4, ICAM-1, Tumor Necrosis Factor Alpha-Induced Protein 3 (TNFAIP3), and Caspase-8 (CASP8) genes that present a role in atherosclerosis development at different level and with different functions were considered."
30356351
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"Genome-wide association study of systemic lupus erythematosus (SLE) revealed tumor necrosis factor alpha induced protein 3 (TNFAIP3, A20) as a susceptibility gene."
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"Analysis of individual A20 kappa B sites revealed that both kappa B sites were required for TNF or PMA activation of the A20 promoter; however, Tax activation required only one kappa B site."
8444879
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"A20, also known as the TNF-alpha-induced protein 3 (TNFAIP3), is a zinc finger protein that was first identified from a gene, TNFAIP3, that was induced by TNF-alpha in human umbilical vein endothelial cells XREF_BIBR; it is now known that A20 is widely expressed in a variety of human cells."
25050625
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"A20 expression is induced by TNF and required for the downregulation of signaling ."
19489724