IndraLab

Statements


USP4 deubiquitinates DDX58. 4 / 4
1 | 3

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"Conversely, USP15 and USP4 deubiquitinate TRIM25 and RIG-I, respectively, to stabilize the proteins."

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"RIG-I can be ubiquitinated and degraded by RNF125 (Ring Finger Protein 125) and deubiquitinated and stabilized by USP4."

"Furthermore, USP4 was found to interact with RIG-I and remove K48-linked polyubiquitination chains from RIG-I."

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"USP4 deubiquitinates and stabilizes RIG-I to promote type I IFN induction after viral infection [83]."