IndraLab

Statements


USP4 deubiquitinates RIGI. 3 / 4
1 | 3

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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."

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"USP4 deubiquitinates and stabilizes RIG-I to promote type I IFN induction after viral infection [83]."

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"RIG-I can be ubiquitinated and degraded by RNF125 (Ring Finger Protein 125) and deubiquitinated and stabilized by USP4."