IndraLab

Statements

KL activates KCNH2. 5 / 6
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"The results reveal that coexpression of klotho up-regulates hERG activity by enhancing the plasma membrane abundance of the channel protein."
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"According to dual electrode voltage clamp in hERG channel expressing Xenopus oocytes, klotho significantly increased the hERG protein abundance within the cell membrane."
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"Klotho deficiency is expected to down-regulate hERG channel activity resulting in delayed repolarisation."
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"At least in theory, the up-regulation of hERG by klotho could thus foster tumour development.In conclusion, klotho participates in the regulation of the voltage-gated K + channel hERG."
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"Klotho enhances hERG activity, an effect apparently requiring glucuronidase activity."
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