IndraLab

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USP4 activates Th17. 3 / 3
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"By isolating T cells from patients with RHD as well as healthy volunteers and detecting the mRNA level of USP4 in CD4 T cells, the researchers found that the mRNA level of USP4 was related to the mRNA level of IL-17 and the function of Th17, indicating that USP4 may mediate the function of Th17 under inflammatory stimulation."
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"Inhibition of the catalytic activity of USP4 with vialinin A, an inhibitor of USP4 isolated from the Chinese mushroom, impairs Th17 differentiation, suggesting that USP4 promotes Th17 differentiation."
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"Conversely, deubiquitination of the K48 linked polyubiquitination of RORgammat by the deubiquitinase ubiquitinspecific protease USP4 stabilizes RORgammat and promotes its activation of Th17 associated genes, whereas inhibition of USP4 activity diminishes Th17 differentiation."
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