IndraLab

Statements

Mutated BAP1 activates Meningioma. 4 / 4
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"Germline BAP1 mutations have also been identified, increasing the hereditary risk of meningiomas and other cancers including uveal melanoma, cutaneous melanoma, and renal cell carcinoma [53, 54]."
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"Initially thought to be sporadic tumors, germline BAP1 mutations were identified in some of these patients, further supporting meningiomas as part of the BAP1 tumor predisposition syndrome spectrum."
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"Germline BAP1 mutations cause mesothelioma and other malignancies, namely, uveal cancer, meningioma, and melanoma, overall defined as “BAP1- related cancer syndrome”."
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"Certain patients with meningiomas caused by BAP1 mutations inherit BAP1 mutations and are diagnosed with BAP1 tumor predisposition syndrome (50,51)."
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