IndraLab

Statements

VEGFA activates PKD1. 3 / 3
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"PKD1 that is activated in endothelial cells by vesicular endothelial growth factor (VEGF) phosphorylates HDAC5 at Ser259/498 and induces cell proliferation and angiogenesis ( xref )."
21680539
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"It appears, therefore, that integrin αvβ3 underwent constitutive Rab5 and Rab4-dependent recycling through early endosomes, and that the activation of PKD1 by VEGF-A inhibited the endocytosis of αvβ3 via an unknown mechanism."
22617029
sparser
"VEGF-A activated PKD1 by inducing its phosphorylation of Ser 744/748 in the activation loop, most likely by protein kinase Cα [ xref ] ( xref )."
22617029