IndraLab

Statements

VEGFA activates PKD1. 5 / 5
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"PKD1 that is activated in endothelial cells by vesicular endothelial growth factor (VEGF) phosphorylates HDAC5 at Ser259/498 and induces cell proliferation and angiogenesis ( xref )."
21680539
sparser
"Additionally, VEGF-A can activate PKD1 to modulate αvβ3 integrin trafficking in endothelial cells, suggesting bidirectional crosstalk between VEGF and integrin receptors [84] ."
22397948
reach
"Additionally, VEGF-A can activate PKD1 to modulate αvβ3 integrin trafficking in endothelial cells, suggesting bidirectional crosstalk between VEGF and integrin receptors [84] ."
22397948
sparser
"VEGF-A activated PKD1 by inducing its phosphorylation of Ser 744/748 in the activation loop, most likely by protein kinase Cα [ xref ] ( xref )."
22617029
sparser
"It appears, therefore, that integrin αvβ3 underwent constitutive Rab5 and Rab4-dependent recycling through early endosomes, and that the activation of PKD1 by VEGF-A inhibited the endocytosis of αvβ3 via an unknown mechanism."
22617029