IndraLab
Statements
OTUD5 inhibits DNA-templated transcription. 2 / 2
|
2
reach
"OTUD5 downregulates the stability of the transcription factor RORγt, which induces IL-17 production in T cells, and interestingly, it does so indirectly by stabilizing UBR5 (43); the model suggested that UBR5 ubiquitinates and degrades RORγt. Therefore, the role of OTUD5 in cytokine production has a similarity with the role described herein, in that it negatively impacts transcription, at least in part through UBR5 stabilization."