IndraLab

Statements

Dihydroartemisinin inhibits CHUK. 5 / 5
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"Interestingly, DHA specifically inhibits IKKalpha and beta and p38 [XREF_BIBR, XREF_BIBR]."
33535710
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"As shown in XREF_SUPPLEMENTARY, DHA reduced Cdk4, Cdk6, VEGF, IKKalpha, and Rac1 levels compared to the control group."
27613829
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"Only treatment with DHA inhibited IkappaBalpha phosphorylation, and this inhibition was mediated by DHA directly blocking the activity of IKKalpha and beta and p38, likely competing for the binding of ATP to the active site of IKKbeta [XREF_BIBR, XREF_BIBR]."
33535710
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"We discovered that DHA directly inhibits IkappaBalpha kinase beta (IKKbeta) and IKKalpha enzymatic activity in vitro, whereas AA did not have this effect."
15254232
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"AA quenches ROS intermediates involved in the activation of NF-kappaB and is oxidized to DHA, which directly inhibits IKKbeta and IKKalpha enzymatic activity."
15254232