IndraLab

Statements

USP25 activates DNA Damage. 3 / 3
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"Liu et al. reported that USP21 enhanced the ability of tumor cells to repair DNA damage by interacting, deubiquitinating, and stabilizing BRCA2 in hepatocellular cancer [20]."
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"As a result, depletion of USP21 decreases homologous recombination efficiency, causes an increase in DNA damage load and impairs tumor cell survival."
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"In addition, USP25 significantly increases the abundance of BARD1 protein and prevents HDM-induced DNA damage and inflammation [90] ."
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