IndraLab

Statements

Modified USP8 decreases the amount of FLIP. 3 / 3
| 3
reach
"Overexpression of USP8 increased c-FLIP S ubiquitination, decreased FLIP S half-life, decreased FLIP S steady-state levels, and decreased TRAIL resistance (XREF_FIG)."
22348197
reach
"Over-expression of WT USP8, but not catalytically inactive USP8, increased FLIP S ubiquitination, decreased FLIP S half-life, decreased FLIP S steady-state levels, and decreased TRAIL resistance, while siRNA mediated suppression of USP8 levels had the opposite effects."
20484045
reach
"Furthermore, the suppression of FLIP S levels by USP8 over-expression was reversed by introduction of siRNA targeting AIP4."
20484045