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USP18 leads to the dephosphorylation of IKK_complex. 2 / 2

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"Conversely, knockdown of USP18 in THP-1 and THP-1-derived macrophages enhanced the phosphorylation of IKK, the degradation of IKBalpha and expression of proinflammatory cytokines, such as IL-6, TNF-alpha and IL-1beta in response to LPS treatment These results suggest that USP18 is a novel negative regulator of NF-kappaB signaling."

26240016

➶

reach

"We also found that USP18 blocked IKK phosphorylation by inhibiting the ubiquitination of NEMO."

26620909

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IndraLab

Statements

USP18 leads to the dephosphorylation of IKK_complex. 2 / 2

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