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Dihydrogen inhibits KCNH2. 2 / 2

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"In doing so, we identify a site and mechanism of action of the well-known proton-induced acceleration of hERG channel deactivation gating."

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"Thus, it reflects that presence of two hydrogen bond acceptor groups in NCEs that complements N1-N1 hotspots of hydrogen bond donor probes at a distance of 5.6-6.0 Adegrees may reduce the hERG inhibition potential."

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IndraLab

Statements

Dihydrogen inhibits KCNH2. 2 / 2

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