IndraLab

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UCHL1 inhibits STAT1. 2 / 2
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"UCHL1 inhibition promotes the activation of NF-kappaB and STAT1 signaling."

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"These data together suggest that UCHL1 also negatively regulates the NF-kappaB and STAT1 pathway to inhibit the immunosuppressive capacity and IDO expression of human MSCs, indicating an essential role of UCHL1 to regulate the immunosuppressive capacity of both human and murine MSCs."