IndraLab

Statements

MTORC1 binds OTUD5. 2 / 2
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"Results showed that either silencing OTUD5 or treating with rapamycin, the MTORC1 inhibitor, abolished the protective effect of tanshinone IIA against entrectinib-induced cardiomyocyte apoptosis (Figure S6R through 6T), suggesting that restoration of OTUD5-MTORC1 signaling is a critical mechanism through which tanshinone IIA exerts its cardioprotective function."
41115073
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"Entrectinib activates autophagy in cardiomyocytes by directly binding to HMGB1 and promoting its entry into the nucleus, thereby inhibiting downstream OTUD5-MTORC1 signaling."
41115073