IndraLab

Statements

CYLD inhibits TLR3. 4 / 4
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"We hypothesized that the inhibition of CYLD cleavage by a caspase inhibitor may attenuate the activation of the TLR3 and RIG-I pathways."
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"CYLD may prevent excessive inflammation due to an antiviral innate immune response by suppressing IKK complex and NF-κB activation downstream of TLR3 in hRPTECs."
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"Cylindromatosis (CYLD), a Deubiquitinase, Attenuates Inflammatory Signaling Pathways by Activating Toll Like Receptor 3 in Human Mesangial Cells."
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"However, the specific CYLD target modulating TLR3 and TLR4 responses remains to be determined XREF_BIBR (Sidebar A)."
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