IndraLab

Statements

PROC inhibits KCNH2. 4 / 4
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"Second, this study details for the first time the mechanism of I HERG inhibition by PROC."
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"First, they provide information regarding potency of inhibition of I HERG by PROC under conditions that allow direct and reliable comparison with previous data on the other Cl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, relatively little I HERG blockade by PROC (~ 10%) might normally be anticipated to occur at clinically relevant concentrations.The comparatively lower potency blockade of I HERG for PROC than th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In order to assess I HERG blockade by PROC, the voltage protocol shown in Fig. 1A (lower trace) was employed and I HERG tail amplitude was measured on repolarisation to -40 mV after voltage commands t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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