IndraLab

Statements

USP22 activates regulation of cell cycle. 6 / 6
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"The siRNA-mediated knock-down of USP22 could effectively induce cell cycle arrest by regulating target molecules, such as cyclin D2, p21, p15 and p53, and could also inhibit cell growth."
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"In this study, we used siRNA to specifically suppress expression of USP22, and we observed that the knock-down of USP22 could effectively inhibit HeLa cell proliferation and induce cell cycle arrest."
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"USP22 knockdown inhibits cell proliferation and induces cell cycle arrest in IEC-6 cells after hypoxia/reoxygenation injury."
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"Mechanistic analysis has further demonstrated that knockdown of ALKBH5 induces cell cycle arrest by destabilizing ubiquitin-specific peptidase (USP22) and ubiquitin ligase ring finger protein 40 (RNF40), resulting in the upregulation of p27Kip1 and Wee1, which are cyclin-dependent kinase inhibitory proteins, and downregulation of cell cycle and DNA damage and repair-related genes in osteosarcoma cells."
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"Our study also shows that USP22 silencing in GC cells decreases cell proliferation and induces cell cycle arrest and apoptosis in vitro, and suppresses tumor growth and metastasis in vivo."
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"Therefore, up-regulation of USP22 expression will lead to abnormal activation of multiple pathways to promote cell survival while down-regulation of USP22 expression can induce cell cycle arrest at G0/G1 phase in different types of cancer cells (Zhang et al., 2008)."
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