IndraLab

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PTEN activates OTUD3. 1 / 1
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"Indeed, HAUSP/USP7, Ataxin-3, USP10, USP11, USP13, and OTUD3 have all been identified as PTEN DUBs; HAUSP specifically removes monoubiquitin from PTEN to promote its nuclear export ; Ataxin-3 restricts PTEN transcription ; and USP10, USP11, USP13 and OTUD3 increase PTEN stability in different cancer-specific contexts ."