IndraLab

Statements

USP15 inhibits NFE2L2. 14 / 15
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"USP15 inhibits the transcriptional activity of Nrf2 and the Nrf2 dependent antioxidant response."
23727018
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"Myc-USP15 inhibited the activity of Nrf2 in a concentration dependent manner (XREF_FIG)."
23727018
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"Moreover, USP15 stabilizes the KEAP1-NRF2 complex and promotes the degradation of NRF2."
39500864
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"USP15 negatively regulates Nrf2 through deubiquitination of Keap1."
23727018
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"Taken together, these results further demonstrate that USP15 negatively regulates the Nrf2 antioxidant response."
23727018
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"USP15 negatively regulates Nrf2 through deubiquitination of KEAP1 and affects paclitaxel resistance ."
31659154
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"In accordance, the deubiquitinating enzyme USP15 negatively regulates Nrf2 through deubiquitination of Keap1 [XREF_BIBR]."
32234331
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"Recent studies have demonstrated that inhibiting USP15 prevents glutamate-induced oxidative stress and neuronal apoptosis by activating the NRF2/heme oxygenase 1 (HO-1) signaling pathway in HT22 cells [141]."
36260224
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"Recently, USP15 has also been shown to increase the Nrf2 degradation, a master regulator of the antioxidant response, by stabilization of Keap1-Cul3 E3 ligase, which is a direct substrate for USP15 ( [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24984263
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"USP15 increases the degradation of Nrf2 by stabilizing the Cul3-Keap1-E3 ubiquitin ligase complex."
23727018
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"In DN, USP15 inhibition can activate Nrf2 to counteract podocyte damage and oxidative stress [201]."
40133964
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"Taken together, these data indicate that USP15 inhibition protects podocytes from HG-induced injury by enhancing Nrf2 activation via Keap1."
34931430
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"In addition, USP15 stabilizes KEAP1 and promotes the degradation of NRF2, leading to the sensitization of cancer cells to chemotherapy [271, 272]."
36694209
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"Both ubiquitin‐specific protease 15 (USP15) and USP7 suppress NRF2 activity through the deubiquitination of KEAP1."
39887666