IndraLab

Statements

BAP1 activates CTNNB1. 4 / 4
| 4
reach
"Mechanistically, PVT1 binds with KLF5 and increases its stability via BAP1, which upregulates beta-catenin signaling, resulting in enhanced TNBC tumorigenesis."
29760406
reach
"PVT1 binding with KLF5 causes KLF5 to stabilise and this elevates the BAP1 levels, which in turn promotes beta-catenin signalling, thus enhancing TNBC carcinogenesis (Li et al., 2018)."
36708551
reach
"BAP1 depletion caused a reduction in mRNA levels of neural crest migration genes (ROBO1), melanocyte differentiation genes (CTNNB1, EDNRB and SOX10) and other genes that are down-regulated in class 2 tumors (LMCD1 and LTA4H)."
21051595
reach
"Studies have reported that BAP1 upregulates β-catenin, which further promotes TNBC tumorigenesis [29]."
38449391