IndraLab

Statements


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"OTUD4 interacts with FGFR1 and stabilizes FGFR1 by deubiquitination."

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"On the other hand, OTUD4 binds to fibroblast growth factor receptor 1 (FGFR1) and reduces FGFR1’s K6 and K27-linked polyubiquitination, thereby indirectly stabilizing CDK1, ultimately influencing the activation of the downstream MAPK signaling pathway."

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"OTUD4 interacts with FGFR1 and stabilizes FGFR1 by deubiquitination."

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"Co-IP and PLA assays found that OTUD4 interacts with FGFR1(Fig. xref , Supplementary Fig. xref )."

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"On the other hand, OTUD4 binds to fibroblast growth factor receptor 1 (FGFR1) and reduces FGFR1's K6 and K27-linked polyubiquitination, thereby indirectly stabilizing CDK1, ultimately influencing the activation of the downstream MAPK signaling pathway."