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USP2 decreases the amount of MDM2. 2 / 4

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"Knockdown of USP2 decreases Mdm2 protein level and increases p53 transcriptional activity."

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"Conversely, the PD-L1 levels were induced upon USP2 inhibition in all cell types regardless of their p53 status.Since Mdm2 levels were induced in p53-positive cells by USP2 inhibition (Fig. 6a, c), we examined whether USP2 inhibition affects Mdm2-mediated degradation of p53."

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IndraLab

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USP2 decreases the amount of MDM2. 2 / 4

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