IndraLab

Statements



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"Using siRNA-mediated JOSD1 knockdown, we confirmed that the loss of JOSD1 could markedly increase the apoptosis of gynecological cancer cells ."

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"In addition, in the FACS analysis, JOSD1 depletion was found to elevate cell apoptosis in colon cancer cells."

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"By stabilizing MCL1, JOSD1 inhibits the mitochondrial apoptosis pathway and exerts antiapoptotic effects."

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"JOSD1 was reported to stabilize MCL1 and inhibit mitochondrial-dependent apoptosis, which subsequently promoted chemotherapy resistance in leukemia [31]."

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"JOSD1 suppresses mitochondrial apoptosis to induce the chemotherapy drug resistance in the gynaecological tumor by deubiquitinating and stabilizing MCL1 (Wu et al., 2020)."

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"Moreover, with the treatment of CDDP, JOSD1 knockdown could increase expression of apoptosis-related proteins and promote cell apoptosis rate."