IndraLab

Statements

Resveratrol inhibits JUN. 12 / 12
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"The combination of ursolic acid + resveratrol inhibited TPA induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds."
26100520
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"In addition, resveratrol prevented TPA induced DNA binding of activator protein-1 (AP-1)."
15630167
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"In monocytic cells, resveratrol induced a miR-663-dependent effect targeting activator protein-1 (AP-1) through the Jun signaling pathway."
22683846
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"It can be seen in the Western blot analysis that resveratrol as well as piceatannol (curcumin-group) and BTB14431 as well as JFD02836 (emodin-group) induced a significant reduction of endogenous c-Jun in a dose dependent manner."
16083495
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"Resveratrol suppresses TNF induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis : potential role of reactive oxygen intermediates and lipid peroxidation."
10843709
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"Myricetin, but not resveratrol, attenuated tumor promoter induced activation of c-fos or activator protein-1."
17693661
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"Resveratrol, which also act as an AhR-antagonist (but may also interfere with NOX signaling and scavenge ROS), suppressed PM 10 -induced CYP1B1 and c-Jun responses, but not IL-6 or CXCL8 in A549 epithelial cells, suggesting that the latter were induced through AhR independent mechanisms [XREF_BIBR]."
26147224
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"Retinal activator protein-1 activation, up-regulated following light exposure, was significantly reduced by application of resveratrol."
20709795
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"To further verify that acetylation decreasing of c-Jun induced by reseveratrol is dependent on Sirt1, we treated T cells isolated from Sirt1 +/+ and Sirt1 -/- mice with resveratrol, and c-Jun were precipitated with anti-c-Jun antibody, then blotted with anti-acetylation antibody and anti-c-Jun antibody, we found that acetylation of c-Jun was significantly decreased in Sirt1 +/+ T cells treated with resveratrol, compared with that in non treated wild type T cells."
24073240
eidos
"In addition , Wang et al. ( 117 ) reported that resveratrol attenuated bleomycin-induced lung fibrosis in mice by inhibiting the MAPK / AP-1 pathway , possibly because resveratrol reduced the levels of c-Fos and c-Jun , thereby inhibiting the miR-21-induced activation of TGF-beta / Smad signaling ."
33693011
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"Resveratrol inhibits the activation of CREB, c-jun, AP-1 and NF-kB transcription factors."
19597034
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"Myricetin, but not resveratrol, attenuated tumor promoter induced activation of c-fos or activator protein-1."
19325788