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Resveratrol inhibits JUN. 21 / 25
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"In addition, pretreatment with the resveratrol derivatives reduced TNF-α-induced ERK1/2, JNK1/2, and c-Jun activation in RMCs."
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"It can be seen in the Western blot analysis that resveratrol as well as piceatannol (curcumin-group) and BTB14431 as well as JFD02836 (emodin-group) induced a significant reduction of endogenous c-Jun in a dose dependent manner."
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"To further verify that acetylation decreasing of c-Jun induced by reseveratrol is dependent on Sirt1, we treated T cells isolated from Sirt1 +/+ and Sirt1 -/- mice with resveratrol, and c-Jun were precipitated with anti-c-Jun antibody, then blotted with anti-acetylation antibody and anti-c-Jun antibody, we found that acetylation of c-Jun was significantly decreased in Sirt1 +/+ T cells treated with resveratrol, compared with that in non treated wild type T cells."
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"Myricetin, but not resveratrol, attenuated tumor promoter induced activation of c-fos or activator protein-1."
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"Furthermore, in both monocytic U937 cells and alveolar epithelial A549 cells, resveratrol inhibits NF-κB and activator protein-1 (AP-1) activation [45,46] ."
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"In addition , Wang et al. ( 117 ) reported that resveratrol attenuated bleomycin-induced lung fibrosis in mice by inhibiting the MAPK / AP-1 pathway , possibly because resveratrol reduced the levels of c-Fos and c-Jun , thereby inhibiting the miR-21-induced activation of TGF-beta / Smad signaling ."
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"Retinal activator protein-1 activation, up-regulated following light exposure, was significantly reduced by application of resveratrol."
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"Manna, S.K., Mukhopadhyay, A. and Aggrawal, B.B. (2000) " Resveratrol suppresses TNF induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis : potential role of reactive oxygen intermediates and lipid peroxidation ", J. Immunol."
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"In addition, resveratrol effectively prevented 4-hydroxynonenal-induced JNK/c-Jun and caspase activation, and hence apoptosis ( Kutuk et al., 2006 )."
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"In monocytic cells, resveratrol induced a miR-663-dependent effect targeting activator protein-1 (AP-1) through the Jun signaling pathway."
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"Myricetin, but not resveratrol, attenuated tumor promoter induced activation of c-fos or activator protein-1."
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"Resveratrol suppresses TNF induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis : potential role of reactive oxygen intermediates and lipid peroxidation."
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"Resveratrol suppresses TNF induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis : potential role of reactive oxygen intermediates and lipid peroxidation."
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"In DMBA-treated skin cancer bearing female CD-1 mice, a maximal ingestion of 25 μmol resveratrol for 18 weeks two times/week downregulated COX-1, COX-2, c-Myc, c-Fos, c-Jun, TGF- β and TNF-α and reduc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, resveratrol prevented TPA induced DNA binding of activator protein-1 (AP-1)."
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"Resveratrol, which also act as an AhR-antagonist (but may also interfere with NOX signaling and scavenge ROS), suppressed PM 10 -induced CYP1B1 and c-Jun responses, but not IL-6 or CXCL8 in A549 epithelial cells, suggesting that the latter were induced through AhR independent mechanisms [XREF_BIBR]."
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"MANNA SK, MUKHOPADHYAY A, AGGARWAL BB : Resveratrol suppresses TNF induced activation of nuclear transcription factors NF-kappaB, activator protein-1 and apoptosis : potential role of reactive oxygen intermediates and lipid peroxidation."
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"Resveratrol inhibits the activation of NF-kB and the activator protein-1 in monocytic U937 and epithelial A549 cells ( Manna et al., 2000; Donnelly et al., 2004 ), as well as reducing expression of in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Resveratrol suppresses TNF induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis : potential role of reactive oxygen intermediates and lipid peroxidation."
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"In addition, Manna et al. (2000) observed that resveratrol suppresses tumor necrosis factor-induced activation of the nuclear transcription factors NF-κB and activator protein-1, as well as impeding a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Resveratrol inhibits the activation of CREB, c-jun, AP-1 and NF-kB transcription factors."
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