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USP5 activates Neoplasms. 28 / 28
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"Our data showed that the inhibition of USP5 activity with G9 also effectively suppressed NSCLC tumor growth in vivo, with no significant toxicity."
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"Furthermore, knockdown of USP5 in U251 cells remarkably inhibited tumor growth in vivo ."
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"ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy."
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"To our knowledge, it is for the first time reported that USP5 promotes tumor radioresistance.Stabilization of EphA2 by USP5 is important for increasing NPC cell radioresistance in vitro and in mice."
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"Importantly, silencing of USP5 dramatically blocks Kras -driven tumor growth in mice models, in which silencing of USP5-induced p53-dependent senescence burden plays a key role."
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"On Day 33, the xenografts were collected and weighed, which showed that the tumor weight was also reduced by USP5 knockdown (Figure 3F, P<0.001)."
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"We next explored whether chemical suppression of USP5 activity could inhibit NSCLC tumor growth in mice in vivo."
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"Previous studies revealed that USP5 suppresses ferroptosis and promotes the malignant progression of tumors."
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"Moreover, the inhibition of USP5 suppresses tumor growth in vivo by downregulating PD-L1 expression (23).2.5 USP9X."
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"Our findings indicate an antagonistic role of Leon/USP5 in Atg1/ULK1-mediated autophagy and may provide mechanistic insights into how USP5 promoted tumor growth and progression."
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"These in vivo findings suggest that suppressing USP5 impedes both tumor growth and lung metastasis in CCA, highlighting the potential of USP5 as a therapeutic target for CCA.In the previous decade, a [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It has been reported that USP5 overexpressed in many tumors and implicated in its progression, including pancreatic cancer [6], breast cancer [7], and glioblastoma [8]."
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"Previous studies suggested that USP5 was often elevated in human malignancies [ 42 , 43 ], and USP5 promoted tumor progression via stabilization and deubiquitination of a variety of downstream target [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in Fig. 1i–n and Supplementary Fig. S2j, depletion of USP5 led to significantly reduced xenograft tumor growth, concomitant with elevated p53, p62/SQSTM1, and SA-β-gal staining, and markedly reduced Ki67."
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"Importantly, ectopic expression of Beclin 1, but not Beclin 1 , remarkably rescued the tumor growth inhibited by USP5 depletion."
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"These data suggest that tumor-intrinsic Usp5 promotes tumor growth likely through inducing tumor immune evasion."
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"As shown in Fig. 3e–j and Supplementary Fig. S3c, while USP5 depletion drastically inhibited tumor growth, simultaneous ablation of p53 remarkably restored tumor growth, concomitant with increased Ki67 and autophagosomes as well as decreased p62/SQSTM1."
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"For example, Li et al. showed that USP5 inhibition could significantly slow the growth of pancreatic tumors and promote the tumorigenesis and progression of pancreatic cancer by stabilizing the FoxM1 protein, which provided a basis for USP5 as a potential target for PDAC treatment [84]."
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"Bioinformatic analysis showed that USP5 mRNA was elevated in various tumors compared with normal tissues (Supplementary Fig. 14b)."
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"Of note, we employed HCC patient-derived xenograft (PDX) models to investigate whether the ablation of USP5 enhances tumor sensitivity to anti-PD-1 inhibitors (Fig. 7g)."
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"Despite these limitations, our research significantly contributes to the understanding of how YTHDF1 amplifies ICB efficacy by targeting tumor-associated USP5, thereby enhancing tumor immunogenicity."
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"It has been reported that USP5 promotes tumor proliferation and tumorigenesis through the deubiquitination of histone deacetylase 2 ( HDAC2 ) ( Du et al ., 2019 ) and beta-catenin ( Ma et al ., 2018 ) ."
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"USP5 overexpression notably promoted tumor growth in nude mice, while transduction of shUSP5 decreased the growth rate of xenograft tumors (Figure S1N–P, Supporting Information)."
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"USP5 promotes tumor progression by stabilizing SLUG in bladder cancer."
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"Taking together, our results demonstrated that USP5 inhibited ferroptosis by stabilizing LSH protein to a certain extent in HCC.2.5 USP5 promotes tumor growth dependent on stabilizing LSH."
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"Indeed, knockdown of USP5 expression significantly reduced the tumor-initiating cell frequency by 14.85-fold (Fig. 2F)."
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"Conditional knockout of Usp5 in T cells enhances effector cytokine production and slows tumor growth in mice (11)."
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"Inhibition of USP5 activity suppresses NSCLC cell proliferation in vitro and tumor growth in vivo."
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