IndraLab

Statements

USP5 activates Neoplasms. 7 / 7
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"Our data showed that the inhibition of USP5 activity with G9 also effectively suppressed NSCLC tumor growth in vivo, with no significant toxicity."
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"On Day 33, the xenografts were collected and weighed, which showed that the tumor weight was also reduced by USP5 knockdown (Figure 3F, P<0.001)."
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"Inhibition of USP5 activity suppresses NSCLC cell proliferation in vitro and tumor growth in vivo."
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"Furthermore, knockdown of USP5 in U251 cells remarkably inhibited tumor growth in vivo ."
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"ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy."
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"We next explored whether chemical suppression of USP5 activity could inhibit NSCLC tumor growth in mice in vivo."
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"It has been reported that USP5 promotes tumor proliferation and tumorigenesis through the deubiquitination of histone deacetylase 2 ( HDAC2 ) ( Du et al ., 2019 ) and beta-catenin ( Ma et al ., 2018 ) ."
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