IndraLab

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TNFAIP3 activates cell death. 3 / 3
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"The activation of NF-κB pathway suppresses the activation of RIPK1 and cell death mediated by at least two of its transcriptional targets, TNFAIP3 and CFLAR (CASP8 and FADD Like Apoptosis Regulator, also called c-FLIP) (54, 55)."
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"Remarkably, NGI-1, despite being a tool compound that reduces N -glycosylation of multiple proteins 44 , 45 and that may still carry potentially harmful off-target effects on as yet unknown targets, s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Reconstitution of wild type TNFAIP3 in the TNFAIP3 mutated lymphoma cells induces cell death."
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