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USP15 inhibits Ubiquitin. 10 / 10
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"In accordance, the de-ubiquitination assay in LN-229 cells that were transfected with siUSP15, showed that knockdown of endogenous USP15 increased the incorporation of ubiquitin into HECTD1, as compared to the siRNA control cells."
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"For example, USP15, USP30, and USP35 are known to eliminate the ubiquitin- and parkin-mediated signals, consequently delaying or disrupting mitophagy (5)."
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"Downregulation of Ubiquitin-Specific Protease 15 (USP15) Does Not Provide Therapeutic Benefit in Experimental Mesial Temporal Lobe Epilepsy."
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"In resting T cells, MDM2 was stable even in the absence of USP15; however, the TCR+CD 28 signals stimulated ubiquitin dependent degradation of MDM2, which was negatively regulated by USP15."
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"Although PINK1/Parkin-mediated mitophagy has been well studied, no effective drug targeting this pathway has been employed for the treatment of neurodegenerative diseases.As a negative feedback mechan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overexpression of USP15 reduced ubiquitin accumulation on mitochondria, while depletion rescued mitophagy defects in PD patient derived fibroblasts."
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"USP15, USP30 and USP35 inhibit mitophagy by removing the ubiquitin signal from Parkin targets [46–48]."
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"73 USP15 inhibits the NF‐κB pathway by removing K48‐Ub from IκBα and consequently prevent degradation it."
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"Similarly, ubiquitin activation on Ser65 was attenuated by USP15 and to a greater extent in USP30 overexpressing cells, whereas Parkin activation was lower in cells expressing either USP15 and USP30 (Figure 7A,C)."
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"The OMM localized DUB ubiquitin specific processing proteases USP30 and USP15 antagonize PARKIN activity by cleaving ubiquitin chains on mitochondria."
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