IndraLab

Statements

USP15 inhibits Ubiquitin. 6 / 6
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"The OMM localized DUB ubiquitin specific processing proteases USP30 and USP15 antagonize PARKIN activity by cleaving ubiquitin chains on mitochondria."
28512624
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"Conversely, the deubiquitinase USP15 antagonizes LUBAC by removing K48linked ubiquitin from TRIM25, leading to its stabilization and thereby promoting RIG-I-mediated antiviral signaling (67) ."
28096803
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"73 USP15 inhibits the NF‐κB pathway by removing K48‐Ub from IκBα and consequently prevent degradation it."
33872387
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"Overexpression of USP15 reduced ubiquitin accumulation on mitochondria, while depletion rescued mitophagy defects in PD patient derived fibroblasts."
28064438
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"In accordance, the de-ubiquitination assay in LN-229 cells that were transfected with siUSP15, showed that knockdown of endogenous USP15 increased the incorporation of ubiquitin into HECTD1, as compared to the siRNA control cells."
29299163
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"In resting T cells, MDM2 was stable even in the absence of USP15; however, the TCR+CD 28 signals stimulated ubiquitin dependent degradation of MDM2, which was negatively regulated by USP15."
24777531